Assessment of the Role of Serum 25-Hydroxy Vitamin D Level on Coronary Heart Disease Risk With Stratification Among Patients With Type 2 Diabetes Mellitus

We investigated the role of vitamin D on glycemic regulation and cardiac complications in patients with type 2 diabetes mellitus (T2DM). A total of 1139 patients (49.3% males vs 50.7% females) were included. Information on sociodemographic lifestyle, family history, blood pressure (BP), and coronary...

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Bibliographic Details
Published in:Angiology 2021-01, Vol.72 (1), p.86-92
Main Authors: Bener, Abdülbari, Al-Hamaq, Abdulla O. A. A., Zughaier, Susu M., Öztürk, Mustafa, Ömer, Abdülkadir
Format: Article
Language:English
Subjects:
Adult
Blood Pressure
Body Mass Index
Cholesterol - blood
Cohort Studies
Coronary Disease - epidemiology
Diabetes Mellitus, Type 2 - epidemiology
Female
Glycated Hemoglobin A - analysis
Humans
Male
Middle Aged
Risk Factors
Turkey - epidemiology
Uric Acid - blood
Vitamin D - analogs & derivatives
Vitamin D - blood
Waist Circumference
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Summary:We investigated the role of vitamin D on glycemic regulation and cardiac complications in patients with type 2 diabetes mellitus (T2DM). A total of 1139 patients (49.3% males vs 50.7% females) were included. Information on sociodemographic lifestyle, family history, blood pressure (BP), and coronary heart disease (CHD) complications was collected. Significant differences were found between males and females regarding age-groups (P = .002), body mass index (BMI; P = .008), physical activity (P = .010), sheesha smoking (P = .016), cigarette smoking (P = .002), hypertension (P = .050), metabolic syndrome (P = .026), and CHD (P = .020). There were significant differences between vitamin D deficiency, insufficiency, and sufficiency in relation to age-group (P = .002), income (P = .002), waist circumference (P = .002), hip circumference (P = .028), waist–hip ratio (P = .002), and BMI (P = .002). Further, mean values of hemoglobin, magnesium, creatinine, hemoglobin A1c (HbA1c), total cholesterol, uric acid, and diastolic BP were significantly higher among patients with vitamin D deficiency compared with those with insufficiency and sufficiency. Multiple logistic regression analysis revealed that 25-hydroxy vitamin D, 25(OH)D, HbA1c, waist circumference, uric acid, duration of T2DM, total cholesterol, systolic and diastolic BP, and BMI were strong predictor risk factors for CHD among patients with T2DM. The present study supports that 25(OH)D may have a direct effect on CHD and on its risk factors.
ISSN:0003-3197
1940-1574
DOI:10.1177/0003319720951411