Cytomegalovirus glycoprotein B and N genotypes in pediatric recipients of the hematopoietic stem cell transplant

Clinical significance of the cytomegalovirus (CMV) genotypes in patients undergoing allogeneic hematopoietic stem cell transplant (HSCT) has been evaluated mostly in adults. The studies of diverse CMV glycoprotein B (gB) and N (gN) genotype variants in transplanted children and adolescents are lacki...

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Published in:Virology (New York, N.Y.) N.Y.), 2020-09, Vol.548, p.168-173
Main Authors: Janković, Marko, Ćupić, Maja, Knežević, Aleksandra, Vujić, Dragana, Soldatović, Ivan, Zečević, Željko, Gobeljić, Borko, Jovanović, Tanja
Format: Article
Language:English
Subjects:
Cytomegalovirus
gB genotype variants
gN genotype variants
Graft-versus-host disease
Hematopoietic stem cell transplant
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Summary:Clinical significance of the cytomegalovirus (CMV) genotypes in patients undergoing allogeneic hematopoietic stem cell transplant (HSCT) has been evaluated mostly in adults. The studies of diverse CMV glycoprotein B (gB) and N (gN) genotype variants in transplanted children and adolescents are lacking. We analyzed the investment of gB and gN genotype variants in the HSCTed children and their relation to clinical complications and disease outcome. The cohort included forty two pediatric recipients of the HSCT. Patients positive for CMV DNAemia (24/42, 57.1%) were genotyped. The gB4 and gN1 genotype variants predominated and were evidenced in 7/18 (38.9%) and 9/19 (47.4%) patients, respectively. The graft-versus-host disease (GvHD) predominated in children with viremia (p 
ISSN:0042-6822
1096-0341
DOI:10.1016/j.virol.2020.07.010