Shear wave elastography for evaluation of the urgency of liver transplantation in pediatric patients with biliary atresia

Background To investigate the role of two‐dimensional shear wave elastography (2D‐SWE) in the preoperative evaluation of pediatric patients with biliary atresia awaiting liver transplantation. Methods Among a total of 152 pediatric patients enrolled in this single‐institution prospective study betwe...

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Bibliographic Details
Published in:Pediatric transplantation 2020-12, Vol.24 (8), p.e13815-n/a
Main Authors: Gu, Li‐hong, Gu, Guang‐xiang, Fang, Hua, Xia, Qiang, Li, Feng‐hua
Format: Article
Language:English
Subjects:
Age
Ascites
Biliary atresia
Blood
Blood tests
Children
Correlation analysis
Hepatic artery
Liver
liver stiffness measurement
Liver transplantation
Liver transplants
pediatric
Pediatrics
Portal vein
shear wave elastography
Spleen
Ultrasonic imaging
Ultrasound
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Summary:Background To investigate the role of two‐dimensional shear wave elastography (2D‐SWE) in the preoperative evaluation of pediatric patients with biliary atresia awaiting liver transplantation. Methods Among a total of 152 pediatric patients enrolled in this single‐institution prospective study between March 2018 and August 2019, 143 patients (age range, 4‐97 months; median age, 7 months; 84 males, 59 females) who underwent successful routine ultrasound examination, SWE examination, and blood test before liver transplantation were included in the final analysis. The values of liver stiffness measured by SWE were compared with ultrasound and blood test parameters by Spearman's correlation analysis. Results The overall median liver stiffness with 2D‐SWE was 29.0 ± 10.9 kPa, with a range of 9.0‐53.3 kPa. The success rate of 2D‐SWE measurements was 98.0% (149/152). Liver stiffness measurement (LSMs) had no significant correlation with gender, age, weight, and height of the pediatric recipients. LSMs were correlated with ultrasound parameters including portal vein (PV) maximum velocity, PV direction, hepatic artery resistance index (HARI), spleen diameter, ascites, and blood test parameters (albumin level, platelet count level, and international normalized ratio). In the pediatric recipients with hepatofugal PV flow, high HARI (HARI ≧ 0.90), and ascites, or without Kasai operation, LSMs were significantly higher (P 
ISSN:1397-3142
1399-3046
DOI:10.1111/petr.13815