Practitioner Review: Pharmacological treatment of attention‐deficit/hyperactivity disorder symptoms in children and youth with autism spectrum disorder: a systematic review and meta‐analysis

Background Clinically significant attention‐deficit/hyperactivity disorder (ADHD) symptoms are common and impairing in children and youth with autism spectrum disorder(ASD). The aim of this systematic review and meta‐analysis was to (a) evaluate the efficacy and safety of pharmacotherapy for the tre...

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Bibliographic Details
Published in:Journal of child psychology and psychiatry 2021-06, Vol.62 (6), p.680-700
Main Authors: Rodrigues, Rebecca, Lai, Meng‐Chuan, Beswick, Adam, Gorman, Daniel A., Anagnostou, Evdokia, Szatmari, Peter, Anderson, Kelly K., Ameis, Stephanie H.
Format: Article
Language:English
Subjects:
ADHD
alpha‐2 agonists
Amphetamines
Antidepressants
antipsychotics
Atomoxetine
Attention Deficit Disorders
Attention deficit hyperactivity disorder
Autism
autism spectrum disorder
Autism Spectrum Disorders
Autistic children
Bupropion
Child & adolescent psychiatry
Children & youth
Clinical decision making
Clinical research
Clinical significance
Clinical trials
Critical incidents
Dropping out
Drug therapy
Drugs
Efficacy
Evidence
Hyperactivity
Impulsivity
inattention
Meta-analysis
Methylphenidate
Modafinil
Parents
pervasive developmental disorder
Pharmacology
pharmacotherapy
Psychotropic drugs
Randomized Controlled Trials
Stimulants
Systematic review
Teachers
Translation
Treatment methods
tricyclic antidepressants
venlafaxine
Youth
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Summary:Background Clinically significant attention‐deficit/hyperactivity disorder (ADHD) symptoms are common and impairing in children and youth with autism spectrum disorder(ASD). The aim of this systematic review and meta‐analysis was to (a) evaluate the efficacy and safety of pharmacotherapy for the treatment of ADHD symptoms in ASD and (b) distil findings for clinical translation. Methods We searched electronic databases and clinical trial registries (1992 onwards). We selected randomized controlled trials conducted in participants
ISSN:0021-9630
1469-7610
DOI:10.1111/jcpp.13305