Intraocular pressure following four different intravenous sedation protocols in normal horses

Background Intravenous sedation is frequently necessary for ophthalmic examination in horses. Common sedation protocols have not been directly compared in terms of relative intraocular pressure (IOP) reduction, duration of IOP reduction and time to maximum IOP reduction. Objectives To compare the ef...

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Bibliographic Details
Published in:Equine veterinary journal 2021-05, Vol.53 (3), p.612-617
Main Authors: Joyner, Rebekah L., Liu, Chin‐Chi, Cremer, Jeannette, Carter, Renee T., Lewin, Andrew C.
Format: Article
Language:English
Subjects:
Animals
Butorphanol
Eye Diseases - veterinary
glaucoma
horse
Horse Diseases
Horses
Intraocular Pressure
sedatives
Tonometry, Ocular - veterinary
uveitis
Xylazine - pharmacology
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Summary:Background Intravenous sedation is frequently necessary for ophthalmic examination in horses. Common sedation protocols have not been directly compared in terms of relative intraocular pressure (IOP) reduction, duration of IOP reduction and time to maximum IOP reduction. Objectives To compare the effects of standing sedation protocols on IOP. Study design Randomised cross‐over experiment. Methods Twelve healthy horses received four intravenous sedation protocols with a 48 hours washout: 0.5 mg/kg xylazine and 0.01 mg/kg butorphanol (SED1); 10 µg/kg detomidine and 0.01 mg/kg of butorphanol (SED2); 10 µg/kg detomidine (SED3); 0.5 mg/kg xylazine (SED4). IOP was measured with rebound tonometry before sedation (Tpre) and 5, 10, 15, 30, 45 and 60 minutes post‐sedation (Tpost). Post‐sedation readings were taken with the head elevated to the Tpre position. Separately, IOP readings were also obtained following sedation with the head not elevated (TpostHeadDown). IOP values were compared using mixed ANOVA and ANCOVA models respectively with significance at P 
ISSN:0425-1644
2042-3306
DOI:10.1111/evj.13336