Alterchromanone A, one new chromanone derivative from the mangrove endophytic fungus Alternaria longipes

One new chromanone derivative, alterchromanone A ( 1 ), and four known curvularin-type macrolides ( 2 – 5 ) were isolated from the crude extract of the mangrove-derived endophytic fungus Alternaria longipes . Their structures were elucidated by MS and NMR spectroscopic analyses and by a comparison w...

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Bibliographic Details
Published in:Journal of antibiotics 2021-02, Vol.74 (2), p.152-155
Main Authors: Liu, Gaoran, Niu, Shubin, Liu, Ling
Format: Article
Language:English
Subjects:
631/1647/2258/878
631/1647/296
82/58
Antibiotics
Bacteriology
Biomedical and Life Sciences
Bioorganic Chemistry
Brief Communication
Carbon
Fungi
Life Sciences
Medicinal Chemistry
Metabolites
Microbiology
Natural products
Organic Chemistry
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Summary:One new chromanone derivative, alterchromanone A ( 1 ), and four known curvularin-type macrolides ( 2 – 5 ) were isolated from the crude extract of the mangrove-derived endophytic fungus Alternaria longipes . Their structures were elucidated by MS and NMR spectroscopic analyses and by a comparison with data from the literature. The absolute configuration of 1 was assigned by combination of experimental and calculated electronic circular dichroism (ECD) spectra. Compound 1 exhibited 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging activity with an IC 50 value of 56.3 μg ml −1 . According to the structural features of these compounds, the plausible biosynthetic pathways of 1 – 5 were also proposed.
ISSN:0021-8820
1881-1469
DOI:10.1038/s41429-020-00364-4