Interorgan communication in development and cancer

Studies in model organisms have demonstrated that extensive communication occurs between distant organs both during development and in diseases such as cancer. Organs communicate with each other to coordinate growth and reach the correct size, while the fate of tumor cells depend on the outcome of t...

Full description

Saved in:
Bibliographic Details
Published in:Wiley interdisciplinary reviews. Developmental biology 2021-07, Vol.10 (4), p.e394-n/a
Main Authors: Alvarez‐Ochoa, Edel, Froldi, Francesca, Cheng, Louise Y.
Format: Article
Language:English
Subjects:
Animals
Communication
Drosophila
Drosophila - growth & development
Drosophila Proteins - metabolism
Embryogenesis
Embryonic Development
Immune system
Insects
Neoplasms - pathology
organ growth
Organogenesis
Signal Transduction
systemic growth
Tumor cells
tumour growth | organ crosstalk | Drosophila melanogaster
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Studies in model organisms have demonstrated that extensive communication occurs between distant organs both during development and in diseases such as cancer. Organs communicate with each other to coordinate growth and reach the correct size, while the fate of tumor cells depend on the outcome of their interaction with the immune system and peripheral tissues. In this review, we outline recent studies in Drosophila, which have enabled an improved understanding of the complex crosstalk between organs in the context of both organismal and tumor growth. We argue that Drosophila is a powerful model organism for studying these interactions, and these studies have the potential for improving our understanding of signaling pathways and candidate factors that mediate this conserved interorgan crosstalk. This article is categorized under: Establishment of Spatial and Temporal Patterns > Regulation of Size, Proportion, and Timing Early Embryonic Development > Development to the Basic Body Plan Invertebrate Organogenesis > Flies
ISSN:1759-7684
1759-7692
DOI:10.1002/wdev.394