Expression of connexin 43 by atypical fibroxanthoma

Introduction Connexins are transmembrane channel proteins that interconnect adjacent cells and allow the exchange of signaling molecules between cells and the extracellular milieu. They have been investigated in many tumors to obtain information about tumor nature, behavior, and prognosis. Methods H...

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Bibliographic Details
Published in:Journal of cutaneous pathology 2021-02, Vol.48 (2), p.247-254
Main Authors: Fernandez‐Flores, Angel, Varela‐Vazquez, Adrian, Mayan, Maria D., Fonseca, Eduardo
Format: Article
Language:English
Subjects:
atypical fibroxanthoma
Connexin 43
Connexins
malignant fibrous histiocytoma
Paraffin
pleomorphic dermal sarcoma
Tumors
wound healing
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Summary:Introduction Connexins are transmembrane channel proteins that interconnect adjacent cells and allow the exchange of signaling molecules between cells and the extracellular milieu. They have been investigated in many tumors to obtain information about tumor nature, behavior, and prognosis. Methods Herein, we present a study on the immunohistochemical expression of connexin (Cx) 43 in 16 cases of atypical fibroxanthoma (AFX). For the immunohistochemical staining, a tissue array was obtained from the paraffin‐embedded blocks. Results The expression was membranous and cytoplasmic in all cases. Thirteen cases (81.25%) showed strong staining. In the other three cases (18.75%), the staining was medium. None of the cases showed nuclear staining. Fifteen out of 16 cases showed a diffuse pattern, and only one case showed a focal pattern. Conclusions Our results suggest that Cx43 may play an important role in the natural behavior of AFX.
ISSN:0303-6987
1600-0560
DOI:10.1111/cup.13856