Effects of ethyl hexanoate on activities of sympathetic nerves innervating the brown and white adipose tissues, body temperature, and plasma fatty acids

• Published in: Neuroscience letters 2020-10, Vol.737, p.135319-135319, Article 135319
• Main Authors: Horii, Yuko, Fujisaki, Yoshiyuki, Misonou, Yoshiko, Fuyuki, Risa, Nagai, Katsuya
• Format: Article
• Language: English
• Subjects: Adipose Tissue, Brown - innervation; Adipose Tissue, White - innervation; Animals; Autonomic nerve activity; Body Temperature - drug effects; Brown adipose tissue; Caproates - pharmacology; Ethyl hexanoate; Fatty Acids - blood; Lipolysis; Male; Rats; Rats, Wistar; Sympathetic Nervous System - drug effects; Thermogenesis; Thermogenesis - drug effects; White adipose tissue
• ISSN: 0304-3940; 1872-7972
• DOI: 10.1016/j.neulet.2020.135319

•Ethyl hexanoate injection increase brown adipose tissue sympathetic nerve activity.•Ethyl hexanoate injection increase white adipose tissue sympathetic nerve activity.•Ethyl hexanoate injection enhances thermogenesis and lipolysis.•Autonomic changes due to Ethyl Hexanoate a realize via afferent vagal nerve. The autonomic nervous system (ANS) is implicated in maintaining homeostasis of the internal environment in mammals. Therefore, changes occurring in the ANS can cause alterations of physiological phenomena. Ethyl hexanoate (EH) is known as the aroma component of apples. To study the action of ethyl hexanoate on physiological phenomena, we examined the effect of an intragastric (IG) injection of 1 mL/kg body weight of 0.1 ppm EH solution on sympathetic nerve activity innervating the brown adipose tissue (BAT) and white adipose tissue (WAT) in anesthetized rats. Consequently, IG administration of EH increased activity of the sympathetic nerves innervating both the BAT and WAT. In addition, the effects of the IG injection on body temperature above the interscapular BAT and plasma free fatty acid (FFA) concentration were also examined in conscious rats. In this attempt IG injection of EH elevated both the body temperature and plasma FFA levels. Furthermore, subdiaphragmatic vagotomy eliminated the effects of EH on sympathetic nerves innervating BAT and WAT. These findings suggest that EH causes excitations of sympathetic nerves innervating BAT and WAT, and enhances thermogenesis and lipolysis via the afferent vagus nerve. Thus, these present findings also suggest the possibility that EH might have anti-obesity effects.