Effective synthesis of a hexacyclic-steroid derivative from 4-hydroxyestrone

•The aim of this study was to synthesize a new hexacyclic-steroid derivative.•The results showed a good yielding from the hexacyclic-steroid derivative.•In conclusion, the reagents used do not require special conditions for handling. Several studies have been reported for the preparation of hexacycl...

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Bibliographic Details
Published in:Steroids 2020-11, Vol.163, p.108715-108715, Article 108715
Main Authors: Lauro, Figueroa-Valverde, Francisco, Diaz Cedillo, Marcela, Rosas-Nexticapa, Maria, Lopez-Ramos, Alejandra, Garcimarero-Espino E., Virginia, Mateu-Armand, Yazmin, Ortiz-Ake
Format: Article
Language:English
Subjects:
4-Hydroxyestrone
Derivative
Hexacyclic
Steroid
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Summary:•The aim of this study was to synthesize a new hexacyclic-steroid derivative.•The results showed a good yielding from the hexacyclic-steroid derivative.•In conclusion, the reagents used do not require special conditions for handling. Several studies have been reported for the preparation of hexacyclic-steroid derivatives; however, some reagents are expensive and require special conditions for handling. In this way, the objective of this study was to synthesize a hexacyclic-steroid derivative from 4-hydroxyestrone. The chemical structure was evaluated through both 1H NMR and 13C NMR spectroscopic analysis. The results showed good performance of the hexacyclic-steroid derivative. In conclusion in this study, an easy method for the preparation of the hexacyclic-steroid derivative is reported.
ISSN:0039-128X
1878-5867
DOI:10.1016/j.steroids.2020.108715