Coupling of Laser Ablation and the Liquid Sampling-Atmospheric Pressure Glow Discharge Plasma for Simultaneous, Comprehensive Mapping: Elemental, Molecular, and Spatial Analysis

The spatial distributions of elemental and molecular species are vital pieces of information for a broad number of applications such as material development and bio/environmental analysis. There is currently no single analytical method that can simultaneously acquire elemental, molecular, and spatia...

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Bibliographic Details
Published in:Analytical chemistry (Washington) 2020-09, Vol.92 (18), p.12622-12629
Main Authors: Paing, Htoo W, Bryant, Tyler J, Quarles, C. Derrick, Marcus, R. Kenneth
Format: Article
Language:English
Subjects:
Ablation
Analytical chemistry
Atmospheric Pressure
Caffeine
Chemistry
Chickens
Coupling (molecular)
Glow discharges
Glutamic acid
Ionization
Laser ablation
Lasers
Mapping
Mass spectra
Mass Spectrometry
Microplasmas
Parameters
Polymers - analysis
Poultry
Sampling
Spatial analysis
Spatial data
Spatial distribution
Species
Thallium
Tyrosine - analysis
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Summary:The spatial distributions of elemental and molecular species are vital pieces of information for a broad number of applications such as material development and bio/environmental analysis. There is currently no single analytical method that can simultaneously acquire elemental, molecular, and spatial information from a single sample. This paper presents the coupling of an NWR213 laser ablation (LA) system to the liquid sampling-atmospheric pressure glow discharge (LS-APGD) microplasma for combined atomic and molecular (CAM) analysis. The work demonstrates a fundamental balance that must be considered between the extent of fragmentation of molecules and ionization of atoms for CAM analysis. Detailed studies showed that the interelectrode gap to be a critical parameter for controlling the ionization efficiency of atomic and molecular species. Utilizing Design-of-Experiment (DoE) procedures, the discharge current was also found to be a significant parameter to control. Elemental lead, caffeine, and simultaneous lead and caffeine analysis via LA-LS-APGD-MS was made possible through improved understanding of the influence of plasma parameters on the product mass spectra of laser-ablated particles. Finally, a chemical map of elemental lead and molecular caffeine, from lead nitrate and caffeine residues, was generated, demonstrating the comprehensive mapping capabilities of LA-LS-APGD-MS. The practical relevance of the capabilities is demonstrated by mapping glutamic acid from a cryosectioned chicken breast with a thallium spike deposited within the tissue. It is believed that the LA-LS-APGD-MS could be a valuable methodology for the simultaneous mapping of elemental and molecular species from a variety of samples.
ISSN:0003-2700
1520-6882
DOI:10.1021/acs.analchem.0c02677