Sex Cord Tumor With Annular Tubules–Like Histologic Pattern in Adult Granulosa Cell Tumor: Case Report of a Hitherto Unreported Morphologic Variant

Adult granulosa cell tumor (AGCT) and sex cord tumor with annular tubules (SCTAT) are distinct sex cord stromal tumors with different molecular signatures. We present a unique case of an incidental ovarian tumor with mixed AGCT and SCTAT morphologic patterns. Due to the unusual co-occurrence, molecu...

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Bibliographic Details
Published in:International journal of surgical pathology 2021-06, Vol.29 (4), p.433-437
Main Authors: Chang, Ruby J., Reuther, Jacquelyn, Gandhi, Ilavarasi, Roy, Angshumoy, Jain, Shilpa, Masand, Ramya P.
Format: Article
Language:English
Subjects:
Case reports
Morphology
Ovarian cancer
Ovaries
Reproductive health
Tumors
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Summary:Adult granulosa cell tumor (AGCT) and sex cord tumor with annular tubules (SCTAT) are distinct sex cord stromal tumors with different molecular signatures. We present a unique case of an incidental ovarian tumor with mixed AGCT and SCTAT morphologic patterns. Due to the unusual co-occurrence, molecular testing was separately performed on both components. Despite minimal overlap in morphology, both the SCTAT and AGCT components were found to have an identical mutation profile, including the prototypical FOXL2 p.C134W mutation characteristic of AGCT. We thus present the first report of AGCT with SCTAT-like pattern.
ISSN:1066-8969
1940-2465
DOI:10.1177/1066896920953620