Periconceptional use of cod liver oil, a vitamin D source, could decrease the risk of CHD in offspring

Objective:To explore if there is association between vitamin D supplementation through cod liver oil ingestion around the periconceptional period and the risk of developing severe CHD in offspring. Furthermore, we would examine the interaction between vitamin D and folic acid supplementation in the...

Full description

Saved in:
Bibliographic Details
Published in:Cardiology in the young 2020-10, Vol.30 (10), p.1445-1451
Main Authors: Zhao, Anda, Zhao, Kena, Xia, Yuanqing, Yin, Yong, Zhu, Jianzhen, Hong, Haifa, Li, Shenghui
Format: Article
Language:English
Subjects:
Acids
Body mass index
Calciferol
Children
Confidence intervals
Diabetes
Dietary supplements
Epidemiology
Ethnicity
Fish oils
Folic acid
Health care facilities
Hospitals
Hypertension
Ingestion
Liver
Matching
Multiple births
Normal distribution
Offspring
Pediatrics
Pregnancy
Questionnaires
Risk
Vitamin B
Vitamin D
Vitamin deficiency
Womens health
Citations: Items that this one cites
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Objective:To explore if there is association between vitamin D supplementation through cod liver oil ingestion around the periconceptional period and the risk of developing severe CHD in offspring. Furthermore, we would examine the interaction between vitamin D and folic acid supplementation in the association.Methods:A case–control study was conducted in Shanghai Children’s Medical Center, in which, a total of 262 severe CHD cases versus 262 controls were recruited through June 2016 to December 2017. All children were younger than 2 years. To reduce potential selection bias and to minimise confounding effects, propensity score matching was applied.Results:After propensity score matching, vitamin D supplementation seemed to be associated with decreased odds ratio of severe CHD (odds ratio = 0.666; 95% confidence intervals: 0.449–0.990) in the multivariable conditional logistic analysis. Furthermore, we found an additive interaction between vitamin D and folic acid supplementation (relative excess risk due to interaction = 0.810, 95% confidence intervals: 0.386–1.235) in the association.Conclusion:The results suggested that maternal vitamin D supplementation could decrease the risk of offspring severe CHD; moreover, it could strengthen the protective effect of folic acid. The significance of this study lies in providing epidemiological evidence that vitamin D supplementation around the periconceptional period could be a potential nutritional intervention strategy to meet the challenge of increasing CHD.
ISSN:1047-9511
1467-1107
DOI:10.1017/S1047951120002280