External validation of the YEARS diagnostic algorithm for suspected pulmonary embolism

Background Validated diagnostic algorithms are used to manage patients with suspected pulmonary embolism (PE). The recently published YEARS study proposed a simplified diagnostic strategy to reduce the use of computed tomography pulmonary angiography. Objectives To externally validate this strategy...

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Bibliographic Details
Published in:Journal of thrombosis and haemostasis 2020-12, Vol.18 (12), p.3289-3295
Main Authors: Eddy, Maggie, Robert‐Ebadi, Helia, Richardson, Lydia, Bellesini, Marta, Verschuren, Frank, Moumneh, Thomas, Meyer, Guy, Righini, Marc, Le Gal, Grégoire
Format: Article
Language:English
Subjects:
Algorithms
Angiography
Computed tomography
Confidence intervals
diagnosis
D‐dimer
Embolism
Fibrin Fibrinogen Degradation Products
Hemoptysis
Humans
Prospective Studies
pulmonary embolism
Pulmonary Embolism - diagnostic imaging
Pulmonary embolisms
Retrospective Studies
Thrombosis
venous thromboembolism
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Summary:Background Validated diagnostic algorithms are used to manage patients with suspected pulmonary embolism (PE). The recently published YEARS study proposed a simplified diagnostic strategy to reduce the use of computed tomography pulmonary angiography. Objectives To externally validate this strategy in an independent cohort. Methods We analyzed data from three previous prospective cohort studies of outpatients with suspected PE. We retrospectively applied the YEARS algorithm. The three YEARS clinical criteria are: clinical signs of deep vein thrombosis, hemoptysis, and PE as the most likely diagnosis. If zero YEARS criteria are met, a D‐dimer 
ISSN:1538-7933
1538-7836
1538-7836
DOI:10.1111/jth.15083