Autophagy-mediating microRNAs in cancer chemoresistance

Chemoresistance is a complex phenomenon responsible for failure in response to chemotherapy agents and more than 90% of deaths in cancer patients. MicroRNAs (miRNAs), as a subgroup of non-coding RNAs with lengths between 21 and 25 nucleotides, are involved in various cancer processes like chemoresis...

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Bibliographic Details
Published in:Cell biology and toxicology 2020-12, Vol.36 (6), p.517-536
Main Authors: Jing, Yuanming, Liang, Wenqing, Liu, Jian, Zhang, Lin, Wei, Jianguo, Yang, Jianhui, Zhang, Yu, Huang, Zongliang
Format: Article
Language:English
Subjects:
Autophagy
Biochemistry
Biodegradation
Biomedical and Life Sciences
Cancer
Cell Biology
Cell death
Chemoresistance
Chemotherapy
Environmental stress
Hypoxia
Life Sciences
Lysosomes
MicroRNAs
miRNA
Non-coding RNA
Nucleotides
Organelles
Phagocytosis
Pharmacology/Toxicology
Review
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Summary:Chemoresistance is a complex phenomenon responsible for failure in response to chemotherapy agents and more than 90% of deaths in cancer patients. MicroRNAs (miRNAs), as a subgroup of non-coding RNAs with lengths between 21 and 25 nucleotides, are involved in various cancer processes like chemoresistance via interacting with their target mRNAs and suppressing their expression. Autophagy is a greatly conserved procedure involving the lysosomal degradation of cytoplasmic contents and organelles to deal with environmental stresses like hypoxia and starvation. Autophagy contributes to response to chemotherapy agents: autophagy can act as a protective mechanism for mediating the resistance in response to chemotherapy or can induce autophagic cell death and mediate the sensitivity to chemotherapy. On the other hand, one of the processes targeted by microRNAs in the regulation of chemoresistance is autophagy. Hence, we studied the literatures on chemoresistance mechanisms, the miRNAs’ role in cancer, and the miRNAs’ role in chemoresistance by modulating autophagy. Graphical Abstract
ISSN:0742-2091
1573-6822
DOI:10.1007/s10565-020-09553-1