Recent advances in myeloid-derived suppressor cell biology

In recent years, studying the role of myeloid-derived suppressor cells (MDSCs) in many pathological inflammatory conditions has become a very active research area. Although the role of MDSCs in cancer is relatively well established, their role in non-cancerous pathological conditions remains in its...

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Bibliographic Details
Published in:Frontiers of medicine 2021-04, Vol.15 (2), p.232-251
Main Authors: Yaseen, Mahmoud Mohammad, Abuharfeil, Nizar Mohammad, Darmani, Homa, Daoud, Ammar
Format: Article
Language:English
Subjects:
alloimmune responses
Autoimmune diseases
autoimmune disorders
Biology
Cellular biology
Humans
mature MDSCs
Medicine
Medicine & Public Health
multiple sclerosis
myeloid-derived pro-inflammatory cells (MDPCs)
Myeloid-Derived Suppressor Cells
Neoplasms
non-human primates (rhesus macaques)
pregnancy
Review
Stem cells
Yin-Yang law of MDSCs
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Summary:In recent years, studying the role of myeloid-derived suppressor cells (MDSCs) in many pathological inflammatory conditions has become a very active research area. Although the role of MDSCs in cancer is relatively well established, their role in non-cancerous pathological conditions remains in its infancy resulting in much confusion. Our objectives in this review are to address some recent advances in MDSC research in order to minimize such confusion and to provide an insight into their function in the context of other diseases. The following topics will be specifically focused upon: (1) definition and characterization of MDSCs; (2) whether all MDSC populations consist of immature cells; (3) technical issues in MDSC isolation, estimation and characterization; (4) the origin of MDSCs and their anatomical distribution in health and disease; (5) mediators of MDSC expansion and accumulation; (6) factors that determine the expansion of one MDSC population over the other; (7) the Yin and Yang roles of MDSCs. Moreover, the functions of MDSCs will be addressed throughout the text.
ISSN:2095-0217
2095-0225
DOI:10.1007/s11684-020-0797-2