Oral mucosal lesions in patients with SARS‐CoV‐2 infection. Report of four cases. Are they a true sign of COVID‐19 disease?

Background Vesiculobullous and macular lesions in the oral mucosa have been reported in patients positive for SARS‐CoV‐2 infection. Nonetheless, the significance and physiopathology of oral manifestations have not been clearly established in the clinical progression or outcome of the infection. Aim...

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Bibliographic Details
Published in:Special care in dentistry 2020-11, Vol.40 (6), p.555-560
Main Authors: Cruz Tapia, Roberto Onner, Peraza Labrador, Alberto Jose, Guimaraes, Douglas Magno, Matos Valdez, Luciano Hermios
Format: Article
Language:English
Subjects:
Angina
Betacoronavirus
Case reports
Coronavirus Infections - complications
COVID-19
Hemorrhage
Humans
Infections
Lesions
Mouth Diseases - virology
Mucosa
oral manifestations
Pandemics
Pneumonia, Viral - complications
Pneumonia, Viral - epidemiology
Polymerase chain reaction
SARS-CoV-2
Severe acute respiratory syndrome coronavirus 2
Stomatitis
Thrombosis
Vasculitis
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Summary:Background Vesiculobullous and macular lesions in the oral mucosa have been reported in patients positive for SARS‐CoV‐2 infection. Nonetheless, the significance and physiopathology of oral manifestations have not been clearly established in the clinical progression or outcome of the infection. Aim To describe the clinico‐pathological oral mucosal lesions in four patients with confirmed SARS‐CoV‐2 infection. Methods and Results Four patients with COVID‐19 disease and confirmed by polymerase chain reaction (PCR) presented angina bullosa hemorragica‐like lesion, vascular disorder, and nonspecific stomatitis, one patient with histological analysis demonstrated perivascular reactive lymphocitic infliltrate, focal capillary thrombosis, and hemorrhage. According to the discrimination of other local and systemic conditions and the synchronous onset of oral and systemic symptoms, the diagnosis of oral lesions probably associated with COVID‐19 was established. Conclusion Infection with SARS‐CoV‐2 may result in oral manifestations with various clinical presentations, which presumably support the hypothesis of thrombi formation and vasculitis; nevertheless, these findings need more evidence and a long‐term follow up of patients to accurately establish the significance of the oral mucosa affection in the COVID‐19 disease.
ISSN:0275-1879
1754-4505
DOI:10.1111/scd.12520