Differences in multi-echo chemical shift encoded MRI proton density fat fraction estimation based on multifrequency fat peaks selection in non-alcoholic fatty liver disease patients

To compare the performance of multi-echo chemical-shift-encoded (MECSE) magnetic resonance imaging (MRI) proton density fat fraction (PDFF) estimation, considering three different fat frequency peak combinations, for the quantification of steatosis in patients with non-alcoholic fatty liver disease...

Full description

Saved in:
Bibliographic Details
Published in:Clinical radiology 2020-11, Vol.75 (11), p.880.e5-880.e12
Main Authors: Martí-Aguado, D., Alberich-Bayarri, Á., Martín-Rodríguez, J.L., França, M., García-Castro, F., González-Cantero, J., González-Cantero, Á., Martí-Bonmatí, L.
Format: Article
Language:English
Subjects:
Adipose Tissue - diagnostic imaging
Adipose Tissue - pathology
Cross-Sectional Studies
Fatty Liver - diagnostic imaging
Fatty Liver - pathology
Female
Humans
Liver - diagnostic imaging
Liver - pathology
Magnetic Resonance Imaging
Male
Middle Aged
Non-alcoholic Fatty Liver Disease - diagnostic imaging
Non-alcoholic Fatty Liver Disease - pathology
Prospective Studies
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:To compare the performance of multi-echo chemical-shift-encoded (MECSE) magnetic resonance imaging (MRI) proton density fat fraction (PDFF) estimation, considering three different fat frequency peak combinations, for the quantification of steatosis in patients with non-alcoholic fatty liver disease (NAFLD). The present study was a prospective cross-sectional research of 121 patients with metabolic syndrome and evidence of hepatic steatosis on ultrasound, who underwent a 3 T MRI examination. All patients were studied with a multifrequency MECSE sequence. The PDFF was calculated using six peaks (MECSEp123456), three peaks (MECSEp456), and a single peak (MECSEp5) model. The two simpler fat peak models were compared to the six peaks model, which was considered the reference standard. Linearity was evaluated using linear regression while agreement was described using Bland–Altman analysis. The mean age was 47 (±9) years and BMI was 29.9 (±2.9) kg/m2. Steatosis distribution was 15%/31%/54% (S1/S2/S3, respectively). Compared to MECSEp123456, both models provided linear PDFF measurements (R2= 0.99 and 0.97, MECSEp456 and MECSEp5 respectively). Regression slope (0.92; p
ISSN:0009-9260
1365-229X
DOI:10.1016/j.crad.2020.07.031