Steroidal saponins from Raphia vinifera and their cytotoxic activity

[Display omitted] •The chemical constituents of Raphia vinifera P. Beauv. fruit, were investigated.•Four new steroidal saponins were isolated.•Compounds 1 and 4 exhibited significant cytotoxicity against CCRF-CEM cell lines. Phytochemical analysis of the fruits of Raphia vinifera led to the isolatio...

Full description

Saved in:
Bibliographic Details
Published in:Steroids 2020-11, Vol.163, p.108724-108724, Article 108724
Main Authors: Chi, Godloves Fru, Sop, Rodrigue V.T., Mbaveng, Armelle T., Omollo Ombito, Japheth, Fotso, Ghislain Wabo, Nguenang, Gaëlle S., Kuete, Victor, Efferth, Thomas, Ngadjui, Bonaventure T.
Format: Article
Language:English
Subjects:
Arecaceae
Cytotoxicity
Raphia vinifera
Steroidal saponin
Citations: Items that this one cites
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:[Display omitted] •The chemical constituents of Raphia vinifera P. Beauv. fruit, were investigated.•Four new steroidal saponins were isolated.•Compounds 1 and 4 exhibited significant cytotoxicity against CCRF-CEM cell lines. Phytochemical analysis of the fruits of Raphia vinifera led to the isolation of four new steroidal saponins (1–4), along with six known secondary metabolites (6–10). The structures of the isolated compounds were determined based on the analyses of NMR and mass spectrometric data, and chemical degradation reactions. Among the compounds tested, 1 and 4 showed the most promising cytotoxic activity against the drug-sensitive CCRF-CEM leukemia cell lines, with IC50 values of 3.55 µM and 7.14 µM, respectively.
ISSN:0039-128X
1878-5867
DOI:10.1016/j.steroids.2020.108724