New-generation drug-eluting coronary stents in octogenarians: Patient-level pooled analysis from the TWENTE I-IV trials

Patients aged ≥80 years are often treated with new-generation drug-eluting stents (DES), but data from randomized studies are scarce owing to underrepresentation in most trials. We assessed 1-year clinical outcome of octogenarians treated with new-generation DES versus younger patients. We pooled pa...

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Bibliographic Details
Published in:The American heart journal 2020-10, Vol.228, p.109-115
Main Authors: Ploumen, Eline H., Buiten, Rosaly A., Doggen, Carine J.M., Stoel, Martin G., van Houwelingen, K. Gert, Schotborgh, Carl E., Jessurun, Gillian A.J., Roguin, Ariel, Danse, Peter W., Benit, Edouard, Aminian, Adel, Linssen, Gerard C.M., de Man, Frits H.A.F., Hartmann, Marc, Buiten, Diedrik G., Kok, Marlies M., Zocca, Paolo, von Birgelen, Clemens
Format: Article
Language:English
Subjects:
Bleeding
Blood vessels
Calcification
Cardiovascular disease
Clinical trials
Consent
Consortia
Coronary vessels
Death
Drug delivery
Heart attacks
Heart rate
Hypertension
Implants
Mortality
Myocardial infarction
Patients
Regression analysis
Stents
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Summary:Patients aged ≥80 years are often treated with new-generation drug-eluting stents (DES), but data from randomized studies are scarce owing to underrepresentation in most trials. We assessed 1-year clinical outcome of octogenarians treated with new-generation DES versus younger patients. We pooled patient-level data of 9,204 participants in the TWENTE, DUTCH PEERS, BIO-RESORT, and BIONYX (TWENTE I-IV) randomized trials. The main clinical end point was target vessel failure (TVF), a composite of cardiac death, target vessel–related myocardial infarction (MI), or clinically indicated target vessel revascularization. The 671 octogenarian trial participants had significantly more comorbidities. TVF was higher in octogenarians than in 8,533 patients
ISSN:0002-8703
1097-6744
DOI:10.1016/j.ahj.2020.07.003