Streptozotocin-induced diabetic cardiomyopathy in rats: ameliorative effect of PIPERINE via Bcl2, Bax/Bcl2, and caspase-3 pathways

The objective of present investigation was to appraise the effects of piperine on STZ-induced diabetic cardiomyopathy in rats. Diabetes was induced in Sprague-Dawley rats with intraperitoneal STZ injection, and the rats were assigned to seven groups. Electrocardiograph, hemodynamic, various biochemi...

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Bibliographic Details
Published in:Bioscience, biotechnology, and biochemistry biotechnology, and biochemistry, 2020-12, Vol.84 (12), p.2533-2544
Main Authors: Wang, Yan, Sun, Hui, Zhang, Jianwu, Xia, Zhiyang, Chen, Wei
Format: Article
Language:English
Subjects:
Alkaloids - pharmacology
Alkaloids - therapeutic use
Animals
Apoptosis - drug effects
Bax
bcl-2-Associated X Protein - metabolism
Bcl2
Benzodioxoles - pharmacology
Benzodioxoles - therapeutic use
cTn-I
Diabetic Cardiomyopathies - drug therapy
Diabetic Cardiomyopathies - metabolism
Diabetic Cardiomyopathies - pathology
Diabetic Cardiomyopathies - physiopathology
diabetic cardiomyopathy
Drinking - drug effects
Eating - drug effects
Glutathione - metabolism
Heart - drug effects
Heart - physiopathology
Hemodynamics - drug effects
Male
Malondialdehyde - metabolism
Myocardium - pathology
Nitric Oxide - metabolism
Organ Size - drug effects
Piperidines - pharmacology
Piperidines - therapeutic use
piperine
Polyunsaturated Alkamides - pharmacology
Polyunsaturated Alkamides - therapeutic use
Proto-Oncogene Proteins c-bcl-2 - metabolism
Rats
Rats, Sprague-Dawley
RNA, Messenger - genetics
Streptozocin - adverse effects
Superoxide Dismutase - metabolism
Urine - chemistry
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Summary:The objective of present investigation was to appraise the effects of piperine on STZ-induced diabetic cardiomyopathy in rats. Diabetes was induced in Sprague-Dawley rats with intraperitoneal STZ injection, and the rats were assigned to seven groups. Electrocardiograph, hemodynamic, various biochemical, molecular, and histological parameters were examined. Treatment with piperine significantly (p
ISSN:0916-8451
1347-6947
DOI:10.1080/09168451.2020.1815170