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Primary prophylaxis was associated with lower arthropathy in Colombian men with haemophilia B: A longitudinal analysis (2015‐2019)
Introduction The risk of chronic haemophilic arthropathy (CHA) is related to severity. Evidence suggests that primary prophylaxis (PPr) could reduce CHA incidence and its impact on quality of life. Aim To evaluate the association between PPr and CHA in Colombian males with haemophilia B (HB) during...
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| Published in: | Haemophilia : the official journal of the World Federation of Hemophilia 2020-11, Vol.26 (6), p.e282-e290 |
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| container_end_page | e290 |
| container_issue | 6 |
| container_start_page | e282 |
| container_title | Haemophilia : the official journal of the World Federation of Hemophilia |
| container_volume | 26 |
| creator | Hernández Vargas, Juliana Alexandra Linares, Adriana Solano, María Helena Valbuena, Ana María Acuña, Lizbeth |
| description | Introduction
The risk of chronic haemophilic arthropathy (CHA) is related to severity. Evidence suggests that primary prophylaxis (PPr) could reduce CHA incidence and its impact on quality of life.
Aim
To evaluate the association between PPr and CHA in Colombian males with haemophilia B (HB) during 2015 to 2019.
Methods
A panel‐time analysis was performed with data provided by the National Health System to update a nationwide open cohort of people with congenital coagulopathies. The association was evaluated in a logistic random‐effect regression model (LRERM), adjusted by age at diagnosis, prophylaxis dose and frequency, severity, haemarthrosis and high‐titre inhibitors.
Results
During 2015‐2019, a total of 362 men with HB and treated with either, primary, secondary or tertiary prophylaxis were identified. At baseline, CHA prevalence in the cohort was 36.84% (n = 133), median age was 19.0 years (IQR: 10.0‐27.0), and median age at diagnosis was 1.0 year (IQR: 0.0‐4.0). PPr was prescribed in 37.85% (n = 137), and median dose (IU/Kg/dose) was almost the same for primary vs. secondary/tertiary prophylaxis. Patients in PPr had a lower frequency of severe HB, CHA, haemarthrosis, infectious complications and high‐titre inhibitors than those in secondary or tertiary prophylaxis (STPr). In the LRERM, PPr was associated with a significant reduction of 89.70% in the odds of CHA (aOR = 0.103, IC 95%: 0.040, 0.270; P |
| doi_str_mv | 10.1111/hae.14136 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2440665770</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2440665770</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3536-4060767e06c0da378463fb8bba3334b1886aeb73d5d5b4803f9a7dddf7e82ce3</originalsourceid><addsrcrecordid>eNp1kb9O5DAQxi10iP8FL3CydM1SBOw4trN0y4oDJCQo6KNJ7BAjJ9mLEy3pKHiAe8Z7EmYvQIGEixkXP3_zeT5Cjjk75XjOKrCnPOFCbZE9rDKKJVc_NnfJozTmapfsh_DEGBcxUztkV8TpPE6k3COv952roRvpqmtX1ejh2QW6hkAhhLZw0FtD166vqG_XtqPQ9RWC0FcjdQ1dtr6tcwcNrW0zceilRiXnHdCLc7rAh82j6wfjGvAUsIwBR8xixuW_l7_Y5ieHZLsEH-zRez8gD78vH5bX0e3d1c1ycRsVQgoVJUwxrbRlqmAGhE4TJco8zXMQQiQ5T1MFNtfCSCPzJGWinIM2xpTapnFhxQGZTbL41z-DDX1Wu1BY76Gx7RCyOMEJSmrNEP31BX1qhw7NbyjN0QjTEqmTiSq6NoTOltlq2mbGWbZJJsNtZP-TQfbnu-KQ19Z8kh9RIHA2AWvn7fi9Una9uJwk3wCs55f9</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2471060075</pqid></control><display><type>article</type><title>Primary prophylaxis was associated with lower arthropathy in Colombian men with haemophilia B: A longitudinal analysis (2015‐2019)</title><source>Wiley-Blackwell Read & Publish Collection</source><creator>Hernández Vargas, Juliana Alexandra ; Linares, Adriana ; Solano, María Helena ; Valbuena, Ana María ; Acuña, Lizbeth</creator><creatorcontrib>Hernández Vargas, Juliana Alexandra ; Linares, Adriana ; Solano, María Helena ; Valbuena, Ana María ; Acuña, Lizbeth</creatorcontrib><description>Introduction
The risk of chronic haemophilic arthropathy (CHA) is related to severity. Evidence suggests that primary prophylaxis (PPr) could reduce CHA incidence and its impact on quality of life.
Aim
To evaluate the association between PPr and CHA in Colombian males with haemophilia B (HB) during 2015 to 2019.
Methods
A panel‐time analysis was performed with data provided by the National Health System to update a nationwide open cohort of people with congenital coagulopathies. The association was evaluated in a logistic random‐effect regression model (LRERM), adjusted by age at diagnosis, prophylaxis dose and frequency, severity, haemarthrosis and high‐titre inhibitors.
Results
During 2015‐2019, a total of 362 men with HB and treated with either, primary, secondary or tertiary prophylaxis were identified. At baseline, CHA prevalence in the cohort was 36.84% (n = 133), median age was 19.0 years (IQR: 10.0‐27.0), and median age at diagnosis was 1.0 year (IQR: 0.0‐4.0). PPr was prescribed in 37.85% (n = 137), and median dose (IU/Kg/dose) was almost the same for primary vs. secondary/tertiary prophylaxis. Patients in PPr had a lower frequency of severe HB, CHA, haemarthrosis, infectious complications and high‐titre inhibitors than those in secondary or tertiary prophylaxis (STPr). In the LRERM, PPr was associated with a significant reduction of 89.70% in the odds of CHA (aOR = 0.103, IC 95%: 0.040, 0.270; P < .001), compared with STPr.
Conclusions
PPr decreased the odds of CHA by 89.70% in males with HB in Colombia. Our findings are consistent with previous studies and support the strategy to prescribe PPr to our patients.</description><identifier>ISSN: 1351-8216</identifier><identifier>EISSN: 1365-2516</identifier><identifier>DOI: 10.1111/hae.14136</identifier><identifier>PMID: 32892455</identifier><language>eng</language><publisher>England: Wiley Subscription Services, Inc</publisher><subject>Diagnosis ; Factor IX deficiency ; haemophilia B ; haemophilic arthropathy ; Hemophilia ; men ; Prophylaxis ; Quality of life ; registries</subject><ispartof>Haemophilia : the official journal of the World Federation of Hemophilia, 2020-11, Vol.26 (6), p.e282-e290</ispartof><rights>2020 John Wiley & Sons Ltd</rights><rights>2020 John Wiley & Sons Ltd.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3536-4060767e06c0da378463fb8bba3334b1886aeb73d5d5b4803f9a7dddf7e82ce3</citedby><cites>FETCH-LOGICAL-c3536-4060767e06c0da378463fb8bba3334b1886aeb73d5d5b4803f9a7dddf7e82ce3</cites><orcidid>0000-0001-7429-6850 ; 0000-0001-6183-252X ; 0000-0001-8752-7080 ; 0000-0002-3668-311X ; 0000-0002-7663-6991</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27923,27924</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32892455$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hernández Vargas, Juliana Alexandra</creatorcontrib><creatorcontrib>Linares, Adriana</creatorcontrib><creatorcontrib>Solano, María Helena</creatorcontrib><creatorcontrib>Valbuena, Ana María</creatorcontrib><creatorcontrib>Acuña, Lizbeth</creatorcontrib><title>Primary prophylaxis was associated with lower arthropathy in Colombian men with haemophilia B: A longitudinal analysis (2015‐2019)</title><title>Haemophilia : the official journal of the World Federation of Hemophilia</title><addtitle>Haemophilia</addtitle><description>Introduction
The risk of chronic haemophilic arthropathy (CHA) is related to severity. Evidence suggests that primary prophylaxis (PPr) could reduce CHA incidence and its impact on quality of life.
Aim
To evaluate the association between PPr and CHA in Colombian males with haemophilia B (HB) during 2015 to 2019.
Methods
A panel‐time analysis was performed with data provided by the National Health System to update a nationwide open cohort of people with congenital coagulopathies. The association was evaluated in a logistic random‐effect regression model (LRERM), adjusted by age at diagnosis, prophylaxis dose and frequency, severity, haemarthrosis and high‐titre inhibitors.
Results
During 2015‐2019, a total of 362 men with HB and treated with either, primary, secondary or tertiary prophylaxis were identified. At baseline, CHA prevalence in the cohort was 36.84% (n = 133), median age was 19.0 years (IQR: 10.0‐27.0), and median age at diagnosis was 1.0 year (IQR: 0.0‐4.0). PPr was prescribed in 37.85% (n = 137), and median dose (IU/Kg/dose) was almost the same for primary vs. secondary/tertiary prophylaxis. Patients in PPr had a lower frequency of severe HB, CHA, haemarthrosis, infectious complications and high‐titre inhibitors than those in secondary or tertiary prophylaxis (STPr). In the LRERM, PPr was associated with a significant reduction of 89.70% in the odds of CHA (aOR = 0.103, IC 95%: 0.040, 0.270; P < .001), compared with STPr.
Conclusions
PPr decreased the odds of CHA by 89.70% in males with HB in Colombia. Our findings are consistent with previous studies and support the strategy to prescribe PPr to our patients.</description><subject>Diagnosis</subject><subject>Factor IX deficiency</subject><subject>haemophilia B</subject><subject>haemophilic arthropathy</subject><subject>Hemophilia</subject><subject>men</subject><subject>Prophylaxis</subject><subject>Quality of life</subject><subject>registries</subject><issn>1351-8216</issn><issn>1365-2516</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><recordid>eNp1kb9O5DAQxi10iP8FL3CydM1SBOw4trN0y4oDJCQo6KNJ7BAjJ9mLEy3pKHiAe8Z7EmYvQIGEixkXP3_zeT5Cjjk75XjOKrCnPOFCbZE9rDKKJVc_NnfJozTmapfsh_DEGBcxUztkV8TpPE6k3COv952roRvpqmtX1ejh2QW6hkAhhLZw0FtD166vqG_XtqPQ9RWC0FcjdQ1dtr6tcwcNrW0zceilRiXnHdCLc7rAh82j6wfjGvAUsIwBR8xixuW_l7_Y5ieHZLsEH-zRez8gD78vH5bX0e3d1c1ycRsVQgoVJUwxrbRlqmAGhE4TJco8zXMQQiQ5T1MFNtfCSCPzJGWinIM2xpTapnFhxQGZTbL41z-DDX1Wu1BY76Gx7RCyOMEJSmrNEP31BX1qhw7NbyjN0QjTEqmTiSq6NoTOltlq2mbGWbZJJsNtZP-TQfbnu-KQ19Z8kh9RIHA2AWvn7fi9Una9uJwk3wCs55f9</recordid><startdate>202011</startdate><enddate>202011</enddate><creator>Hernández Vargas, Juliana Alexandra</creator><creator>Linares, Adriana</creator><creator>Solano, María Helena</creator><creator>Valbuena, Ana María</creator><creator>Acuña, Lizbeth</creator><general>Wiley Subscription Services, Inc</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>8FD</scope><scope>FR3</scope><scope>H94</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-7429-6850</orcidid><orcidid>https://orcid.org/0000-0001-6183-252X</orcidid><orcidid>https://orcid.org/0000-0001-8752-7080</orcidid><orcidid>https://orcid.org/0000-0002-3668-311X</orcidid><orcidid>https://orcid.org/0000-0002-7663-6991</orcidid></search><sort><creationdate>202011</creationdate><title>Primary prophylaxis was associated with lower arthropathy in Colombian men with haemophilia B: A longitudinal analysis (2015‐2019)</title><author>Hernández Vargas, Juliana Alexandra ; Linares, Adriana ; Solano, María Helena ; Valbuena, Ana María ; Acuña, Lizbeth</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3536-4060767e06c0da378463fb8bba3334b1886aeb73d5d5b4803f9a7dddf7e82ce3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Diagnosis</topic><topic>Factor IX deficiency</topic><topic>haemophilia B</topic><topic>haemophilic arthropathy</topic><topic>Hemophilia</topic><topic>men</topic><topic>Prophylaxis</topic><topic>Quality of life</topic><topic>registries</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hernández Vargas, Juliana Alexandra</creatorcontrib><creatorcontrib>Linares, Adriana</creatorcontrib><creatorcontrib>Solano, María Helena</creatorcontrib><creatorcontrib>Valbuena, Ana María</creatorcontrib><creatorcontrib>Acuña, Lizbeth</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Haemophilia : the official journal of the World Federation of Hemophilia</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hernández Vargas, Juliana Alexandra</au><au>Linares, Adriana</au><au>Solano, María Helena</au><au>Valbuena, Ana María</au><au>Acuña, Lizbeth</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Primary prophylaxis was associated with lower arthropathy in Colombian men with haemophilia B: A longitudinal analysis (2015‐2019)</atitle><jtitle>Haemophilia : the official journal of the World Federation of Hemophilia</jtitle><addtitle>Haemophilia</addtitle><date>2020-11</date><risdate>2020</risdate><volume>26</volume><issue>6</issue><spage>e282</spage><epage>e290</epage><pages>e282-e290</pages><issn>1351-8216</issn><eissn>1365-2516</eissn><abstract>Introduction
The risk of chronic haemophilic arthropathy (CHA) is related to severity. Evidence suggests that primary prophylaxis (PPr) could reduce CHA incidence and its impact on quality of life.
Aim
To evaluate the association between PPr and CHA in Colombian males with haemophilia B (HB) during 2015 to 2019.
Methods
A panel‐time analysis was performed with data provided by the National Health System to update a nationwide open cohort of people with congenital coagulopathies. The association was evaluated in a logistic random‐effect regression model (LRERM), adjusted by age at diagnosis, prophylaxis dose and frequency, severity, haemarthrosis and high‐titre inhibitors.
Results
During 2015‐2019, a total of 362 men with HB and treated with either, primary, secondary or tertiary prophylaxis were identified. At baseline, CHA prevalence in the cohort was 36.84% (n = 133), median age was 19.0 years (IQR: 10.0‐27.0), and median age at diagnosis was 1.0 year (IQR: 0.0‐4.0). PPr was prescribed in 37.85% (n = 137), and median dose (IU/Kg/dose) was almost the same for primary vs. secondary/tertiary prophylaxis. Patients in PPr had a lower frequency of severe HB, CHA, haemarthrosis, infectious complications and high‐titre inhibitors than those in secondary or tertiary prophylaxis (STPr). In the LRERM, PPr was associated with a significant reduction of 89.70% in the odds of CHA (aOR = 0.103, IC 95%: 0.040, 0.270; P < .001), compared with STPr.
Conclusions
PPr decreased the odds of CHA by 89.70% in males with HB in Colombia. Our findings are consistent with previous studies and support the strategy to prescribe PPr to our patients.</abstract><cop>England</cop><pub>Wiley Subscription Services, Inc</pub><pmid>32892455</pmid><doi>10.1111/hae.14136</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0001-7429-6850</orcidid><orcidid>https://orcid.org/0000-0001-6183-252X</orcidid><orcidid>https://orcid.org/0000-0001-8752-7080</orcidid><orcidid>https://orcid.org/0000-0002-3668-311X</orcidid><orcidid>https://orcid.org/0000-0002-7663-6991</orcidid></addata></record> |
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| source | Wiley-Blackwell Read & Publish Collection |
| subjects | Diagnosis Factor IX deficiency haemophilia B haemophilic arthropathy Hemophilia men Prophylaxis Quality of life registries |
| title | Primary prophylaxis was associated with lower arthropathy in Colombian men with haemophilia B: A longitudinal analysis (2015‐2019) |
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