Effects of Body Weight on Bleeding and Ischemic Events in Patients Undergoing Percutaneous Coronary Intervention　― From the CREDO-Kyoto Registry Cohort-2

• Published in: Circulation Journal 2020/09/25, Vol.84(10), pp.1734-1745
• Main Authors: Yamamoto, Ko, Natsuaki, Masahiro, Yoshikawa, Yusuke, Morimoto, Takeshi, Shiomi, Hiroki, Watanabe, Hirotoshi, Kato, Takao, Saito, Naritatsu, Kadota, Kazushige, Ando, Kenji, Furukawa, Yutaka, Tamura, Toshihiro, Sakamoto, Hiroki, Toyofuku, Mamoru, Inada, Tsukasa, Inoko, Moriaki, Suwa, Satoru, Onodera, Tomoya, Ishii, Katsuhisa, Kanamori, Norio, Kimura, Takeshi, on behalf of the CREDO-Kyoto PCI/CABG Registry Cohort- Investigators
• Format: Article
• Language: English
• Subjects: Aged; Aged, 80 and over; Body Weight; Coronary artery disease; Coronary Artery Disease - epidemiology; Coronary Artery Disease - surgery; Female; Follow-Up Studies; Hemorrhage - epidemiology; Hemorrhage - etiology; Humans; Incidence; Ischemic Stroke - epidemiology; Ischemic Stroke - etiology; Japan - epidemiology; Male; Middle Aged; Myocardial Infarction - epidemiology; Myocardial Infarction - etiology; Percutaneous coronary intervention; Percutaneous Coronary Intervention - adverse effects; Registries; Retrospective Studies; Risk Factors; Treatment Outcome
• ISSN: 1346-9843; 1347-4820; 1347-4820
• DOI: 10.1253/circj.CJ-20-0343

Background:The effect of body weight (BW) on bleeding and ischemic events has not been adequately evaluated in real-world percutaneous coronary intervention (PCI) practice.Methods and Results:12,690 consecutive patients undergoing first PCI in the CREDO-Kyoto registry cohort-2 were divided into 3 groups according to tertiles of BW stratified by sex (male; Tertile 1 [68.0 kg], and female; Tertile 1 [55.8 kg]). Cumulative 5-year incidences of the primary bleeding (GUSTO moderate/severe) and ischemic (myocardial infarction/ischemic stroke) endpoints increased incrementally with decrease in BW in both strata (male Tertiles 1, 2, and 3: 13.7%, 10.3%, and 8.0%, P