Incidence and Impact of Thrombocytopenia in Patients Undergoing Percutaneous Coronary Intervention With Drug-Eluting Stents

•Baseline thrombocytopenia in patients undergoing percutaneous coronary intervention (PCI) with drug-eluting stents is not uncommon.•Thrombocytopenic patients have increased mortality risk after PCI.•Moderate-to-severe thrombocytopenia increases the risk of major bleeding after PCI. Platelets are cr...

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Bibliographic Details
Published in:The American journal of cardiology 2020-11, Vol.134, p.55-61
Main Authors: Park, Sangwoo, Ahn, Jung-Min, Kim, Tae Oh, Park, Hanbit, Cho, Sang-Cheol, Kang, Do-Yoon, Lee, Pil Hyung, Park, Duk-Woo, Park, Seung-Jung
Format: Article
Language:English
Subjects:
Acute coronary syndromes
Angioplasty
Bleeding
Cerebral infarction
Clinical outcomes
Confidence intervals
Coronary artery
Coronary artery disease
Drug delivery
Health hazards
Heart attacks
Heart diseases
Implants
Mortality
Myocardial infarction
Platelets
Risk factors
Stents
Stroke
Thrombocytopenia
Thrombosis
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Summary:•Baseline thrombocytopenia in patients undergoing percutaneous coronary intervention (PCI) with drug-eluting stents is not uncommon.•Thrombocytopenic patients have increased mortality risk after PCI.•Moderate-to-severe thrombocytopenia increases the risk of major bleeding after PCI. Platelets are crucial in the pathophysiology of coronary artery disease and are a major target of antithrombotic agents in patients receiving percutaneous coronary intervention (PCI). We sought to evaluate the incidence and prognostic impact of thrombocytopenia on clinical outcomes in patients undergoing PCI with drug-eluting stents (DES). We evaluated consecutive patients who received PCI with DES in the IRIS-DES registry between April 2008 and December 2017. Patients were divided into 2 groups based on the presence of thrombocytopenia (platelet count
ISSN:0002-9149
1879-1913
DOI:10.1016/j.amjcard.2020.07.059