Critically important antimicrobials are generally not needed to treat nonsevere clinical mastitis in lactating dairy cows: Results from a network meta-analysis

There is ongoing debate regarding whether critically important antimicrobials (CIA) should be used to treat infections in food-producing animals. In this systematic review, we determined whether CIA and non-CIA have comparable efficacy to treat nonsevere bovine clinical mastitis caused by the most c...

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Bibliographic Details
Published in:Journal of dairy science 2020-11, Vol.103 (11), p.10585-10603
Main Authors: Nobrega, Diego B., Naqvi, S. Ali, Dufour, Simon, Deardon, Rob, Kastelic, John P., De Buck, Jeroen, Barkema, Herman W.
Format: Article
Language:English
Subjects:
Animals
Anti-Bacterial Agents - therapeutic use
Cattle
critically important antimicrobial
dairy cow
Escherichia coli
Female
Klebsiella
Lactation
mastitis
Mastitis, Bovine - drug therapy
Mastitis, Bovine - microbiology
Network Meta-Analysis
treatment
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Summary:There is ongoing debate regarding whether critically important antimicrobials (CIA) should be used to treat infections in food-producing animals. In this systematic review, we determined whether CIA and non-CIA have comparable efficacy to treat nonsevere bovine clinical mastitis caused by the most commonly reported bacteria that cause mastitis worldwide. We screened CAB Abstracts, Web of Science, MEDLINE, Scopus, and PubMed for original epidemiological studies that assessed pathogen-specific bacteriological cure rates of antimicrobials used to treat nonsevere clinical mastitis in lactating dairy cows. Network models were fit using risk ratios of bacteriological cure as outcome. A total of 30 studies met inclusion criteria. Comparisons of cure rates demonstrated that CIA and non-CIA had comparable efficacy for treatment of nonsevere clinical mastitis in dairy cattle. Additionally, for cows with nonsevere clinical mastitis caused by Escherichia coli and Klebsiella spp., bacteriological cure rates were comparable for treated versus untreated cows; therefore, there was no evidence to justify treatment of these cases with CIA. Our findings supported that CIA in general are not necessary for treating nonsevere clinical mastitis in dairy cattle, the disease that accounts for the majority of antimicrobial usage in dairy herds worldwide. Furthermore, our findings support initiatives to reduce or eliminate use of CIA in dairy herds.
ISSN:0022-0302
1525-3198
DOI:10.3168/jds.2020-18365