Multicentric Synchronous Giant Cell Granulomas of the Mandible

Multiple central giant cell granulomas of the jaws may be associated with systemic conditions such as hyperparathyroidism, cherubism, Noonan-like syndrome, Ramon syndrome, and Jaffe–Campanacci syndrome.1,2 If clinical examination and laboratory tests do not suggest the diagnosis of hyperparathyroidi...

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Bibliographic Details
Published in:Ear, nose, & throat journal nose, & throat journal, 2022-05, Vol.101 (4), p.NP178-NP179
Main Author: Omami, Galal
Format: Article
Language:English
Subjects:
Bone diseases
Epidemiology
Etiology
Granulomas
Jaw
Pathogenesis
Tumors
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Summary:Multiple central giant cell granulomas of the jaws may be associated with systemic conditions such as hyperparathyroidism, cherubism, Noonan-like syndrome, Ramon syndrome, and Jaffe–Campanacci syndrome.1,2 If clinical examination and laboratory tests do not suggest the diagnosis of hyperparathyroidism or an inherited syndrome, then most children with multiple symmetrical giant cell granulomas represent a form of cherubism. However, there have been rare reports of multiple synchronous giant cell granulomas for which other causes have been excluded.3,4 There is a familial tendency to multiple lesions of this nature in some cases.5Giant cell granuloma of the jaws tends to occur in younger patients, most frequently before the age of 20 years, and it affects twice as many females as males. The lesion may arise in any area of the jaws but is seen more often where there are or have been deciduous teeth (ie, anterior to the first permanent molars).
ISSN:0145-5613
1942-7522
DOI:10.1177/0145561320953230