Cardiac chamber volumes and left ventricular mass in people living with HIV and matched uninfected controls

• Published in: HIV medicine 2020-11, Vol.21 (10), p.625-634
• Main Authors: Krebs‐Demmer, L, Ronit, A, Sigvardsen, PE, Lebech, A‐M, Gerstoft, J, Knudsen, AD, Fuchs, A, Kühl, JT, Nordestgaard, BG, Kofoed, KF, Nielsen, SD
• Format: Article
• Language: English
• Subjects: Abnormalities; cardiac chamber volumes; cardiovascular computed tomography; cardiovascular disease; Cardiovascular diseases; Chambers; Computed tomography; Health risks; HIV; Human immunodeficiency virus; matched controls; Respiratory function; Risk analysis; Risk factors; Sexually transmitted diseases; STD; Ventricle; ventricular mass
• ISSN: 1464-2662; 1468-1293
• DOI: 10.1111/hiv.12916

Objectives People living with HIV (PLWH) have increased risk of cardiovascular diseases compared with uninfected populations. We assessed structural cardiac abnormalities and their associated risk factors in well‐treated PLWH and uninfected controls using multidetector computed tomography (MDCT). Methods People living with HIV and age‐ and sex‐matched uninfected controls underwent MDCT to determine left atrial volume (LAV), left ventricular diastolic volume (LVDV), right ventricular diastolic volume (RVDV) and left ventricular mass (LVM). All outcomes were indexed to body surface area (BSA) (LAVi, LVDVi, RVDVi and LVMi). Results A total of 592 PLWH and 1184 uninfected controls were included in the study. PLWH had smaller mean (SD) LAVi [40 (8) vs. 41 (9) mL/m2; P = 0.002] and LVDVi [61 (13) vs. 65 (14) mL/m2; P