The risk of lymph node metastasis in T1 colorectal cancer: new parameters to assess the degree of submucosal invasion

Purpose In T1 colorectal cancer, the depth is the main factor assessing the degree of submucosal invasion (DSI) to predict the risk of lymph node metastasis (LNM). The width (WSI) and the area of submucosal invasion (ASI) have been suggested as additional parameters to assess the risk of LNM. A revi...

Full description

Saved in:
Bibliographic Details
Published in:International journal of colorectal disease 2021-01, Vol.36 (1), p.41-45
Main Authors: Cracco, Nicola, Todaro, Valentina, Pedrazzi, Giuseppe, Del Rio, Paolo, Haboubi, Najib, Zinicola, Roberto
Format: Article
Language:English
Subjects:
Cancer
Colorectal cancer
Gastroenterology
Hepatology
Internal Medicine
Medicine
Medicine & Public Health
Metastasis
Oncology, Experimental
Proctology
Review
Surgery
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Purpose In T1 colorectal cancer, the depth is the main factor assessing the degree of submucosal invasion (DSI) to predict the risk of lymph node metastasis (LNM). The width (WSI) and the area of submucosal invasion (ASI) have been suggested as additional parameters to assess the risk of LNM. A review of the literature was undertaken on the correlation between WSI and ASI parameters and the incidence of LNM. Methods A Medline, PubMed, and Cochrane Library search was performed to retrieve all studies reporting correlation between WSI/ASI and risk of LNM in T1 colorectal cancer. Results Eight studies including 1727 patients were identified. All considered the degree of WSI and its influence on LNM: seven assessed different width cut-off of submucosal invasion, and one study the mean width of submucosal invasion in patients having or not involved lymph nodes. The WSI was significantly a prognostic factor for LNM ( p  
ISSN:0179-1958
1432-1262
DOI:10.1007/s00384-020-03738-0