Q192R polymorphism in the PON1 gene and nasal polyp in a Turkish population

The pathogenesis of nasal polyps is not completely understood. Oxidative damage contributes to polyp formation in the nasal mucosa. The paraoxonase 1 (PON1) enzyme is an important liver enzyme with high antioxidant activity. In this study, we investigated the correlation between Q192R genotypic poly...

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Bibliographic Details
Published in:Journal of biochemical and molecular toxicology 2021-01, Vol.35 (1), p.e22628-n/a
Main Authors: Solmaz Avcikurt, Ayla, Gencer, Nahit, Yazici, Hasmet
Format: Article
Language:English
Subjects:
Antioxidants
Correlation analysis
Enzymes
Gene polymorphism
Genotype & phenotype
Mucosa
nasal polyps
Paraoxonase
Paraoxonase 1
Pathogenesis
Polymerase chain reaction
Polymorphism
Polyps
PON1
Restriction fragment length polymorphism
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Summary:The pathogenesis of nasal polyps is not completely understood. Oxidative damage contributes to polyp formation in the nasal mucosa. The paraoxonase 1 (PON1) enzyme is an important liver enzyme with high antioxidant activity. In this study, we investigated the correlation between Q192R genotypic polymorphism of the PON1 enzyme and nasal‐polyp disease. The study examined 62 nasal‐polyp patients and 88 controls. PON1 Q192R polymorphism was determined using polymerase chain reaction‐restriction fragment length polymorphism. The genotype distribution of the PON1 gene was significantly different between nasal‐polyp patients (QQ = 69.35%, QR = 25.81%, RR = 4.83%) and healthy controls (QQ = 52.27%, QR = 44.31%, RR = 3.40%). Our results suggest that the PON1 QQ genotype (odds ratio [OR] = 2.066, P = .036) is associated with a higher risk of developing the nasal‐polyp disease while QR genotype (OR = 0.437, P = .021) showed a lower risk.
ISSN:1095-6670
1099-0461
DOI:10.1002/jbt.22628