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Older age is a risk factor for inadequate energy intake during acute, severe IBD and is associated with shorter time to relapse
Effects of nutritional intake on inflammatory bowel disease (IBD) flare resolution are unknown. We hypothesised that nutritional factors during hospitalisation for acute severe IBD are associated with risk of subsequent relapse. We also studied risk factors for inadequate energy intake. Patients adm...
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Published in: | Scandinavian journal of gastroenterology 2020-10, Vol.55 (10), p.1185-1192 |
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container_title | Scandinavian journal of gastroenterology |
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creator | Kulmala, Katja A. Björk, Jan Andersson, Sara Backman, Ann-Sofie Eberhardson, Michael Bresso, Francesca Hedin, Charlotte R. H. |
description | Effects of nutritional intake on inflammatory bowel disease (IBD) flare resolution are unknown. We hypothesised that nutritional factors during hospitalisation for acute severe IBD are associated with risk of subsequent relapse. We also studied risk factors for inadequate energy intake.
Patients admitted to the Karolinska Hospital Gastroenterology ward with IBD flare during 2015-2016 were retrospectively identified. In total, 91 patients were included. Data on nutrition, disease factors, inflammatory markers, and daily energy requirement were extracted. Requirement of new systemic steroid prescription, intensification of biological therapy, readmission, surgery, and calprotectin level were individually used as proxies for disease relapse. Follow-up was one year after discharge. Adjustments for age and sex were made where appropriate.
Overall, 19%, 31%, and 45% of patients had days with energy intake |
doi_str_mv | 10.1080/00365521.2020.1818119 |
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Patients admitted to the Karolinska Hospital Gastroenterology ward with IBD flare during 2015-2016 were retrospectively identified. In total, 91 patients were included. Data on nutrition, disease factors, inflammatory markers, and daily energy requirement were extracted. Requirement of new systemic steroid prescription, intensification of biological therapy, readmission, surgery, and calprotectin level were individually used as proxies for disease relapse. Follow-up was one year after discharge. Adjustments for age and sex were made where appropriate.
Overall, 19%, 31%, and 45% of patients had days with energy intake <30, <50, and <70% of calculated requirement. Older age was associated with a higher number of days with energy intake <30, <50, and <70% of calculated requirement (regression coefficient 0.03, 0.04, 0.06 respectively, p = .012, .017, .008). The number of days with energy intake <30 and <70% of the calculated requirement and the length of the hospitalisation were associated with shorter time to new steroid prescription (hazard ratio 1.3, 1.1, 1.04 respectively, p = .016, .034, .011). CRP and calprotectin were not associated with relapse.
Older age is a predictor of inadequate energy intake during hospitalisation for acute severe IBD. Inadequate energy intake adjusted for age and sex during IBD flare was better predictor of time to the next steroid-requiring relapse than inflammatory markers.]]></description><identifier>ISSN: 0036-5521</identifier><identifier>ISSN: 1502-7708</identifier><identifier>EISSN: 1502-7708</identifier><identifier>DOI: 10.1080/00365521.2020.1818119</identifier><identifier>PMID: 32905738</identifier><language>eng</language><publisher>England: Taylor & Francis</publisher><subject>Gastroenterologi ; IBD in elderly population ; Klinisk medicin ; Medicin och hälsovetenskap ; Nutrition ; real world data ; severe flare of IBD</subject><ispartof>Scandinavian journal of gastroenterology, 2020-10, Vol.55 (10), p.1185-1192</ispartof><rights>2020 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. 2020</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c501t-84c5a5445779794b07b593a02567bea42cd6701427eda643fc4b94582161e3223</citedby><cites>FETCH-LOGICAL-c501t-84c5a5445779794b07b593a02567bea42cd6701427eda643fc4b94582161e3223</cites><orcidid>0000-0002-4921-8516 ; 0000-0002-8888-0529</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,780,784,885,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32905738$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttp://kipublications.ki.se/Default.aspx?queryparsed=id:144623780$$DView record from Swedish Publication Index$$Hfree_for_read</backlink></links><search><creatorcontrib>Kulmala, Katja A.</creatorcontrib><creatorcontrib>Björk, Jan</creatorcontrib><creatorcontrib>Andersson, Sara</creatorcontrib><creatorcontrib>Backman, Ann-Sofie</creatorcontrib><creatorcontrib>Eberhardson, Michael</creatorcontrib><creatorcontrib>Bresso, Francesca</creatorcontrib><creatorcontrib>Hedin, Charlotte R. H.</creatorcontrib><title>Older age is a risk factor for inadequate energy intake during acute, severe IBD and is associated with shorter time to relapse</title><title>Scandinavian journal of gastroenterology</title><addtitle>Scand J Gastroenterol</addtitle><description><![CDATA[Effects of nutritional intake on inflammatory bowel disease (IBD) flare resolution are unknown. We hypothesised that nutritional factors during hospitalisation for acute severe IBD are associated with risk of subsequent relapse. We also studied risk factors for inadequate energy intake.
Patients admitted to the Karolinska Hospital Gastroenterology ward with IBD flare during 2015-2016 were retrospectively identified. In total, 91 patients were included. Data on nutrition, disease factors, inflammatory markers, and daily energy requirement were extracted. Requirement of new systemic steroid prescription, intensification of biological therapy, readmission, surgery, and calprotectin level were individually used as proxies for disease relapse. Follow-up was one year after discharge. Adjustments for age and sex were made where appropriate.
Overall, 19%, 31%, and 45% of patients had days with energy intake <30, <50, and <70% of calculated requirement. Older age was associated with a higher number of days with energy intake <30, <50, and <70% of calculated requirement (regression coefficient 0.03, 0.04, 0.06 respectively, p = .012, .017, .008). The number of days with energy intake <30 and <70% of the calculated requirement and the length of the hospitalisation were associated with shorter time to new steroid prescription (hazard ratio 1.3, 1.1, 1.04 respectively, p = .016, .034, .011). CRP and calprotectin were not associated with relapse.
Older age is a predictor of inadequate energy intake during hospitalisation for acute severe IBD. Inadequate energy intake adjusted for age and sex during IBD flare was better predictor of time to the next steroid-requiring relapse than inflammatory markers.]]></description><subject>Gastroenterologi</subject><subject>IBD in elderly population</subject><subject>Klinisk medicin</subject><subject>Medicin och hälsovetenskap</subject><subject>Nutrition</subject><subject>real world data</subject><subject>severe flare of IBD</subject><issn>0036-5521</issn><issn>1502-7708</issn><issn>1502-7708</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>0YH</sourceid><recordid>eNp9kc1u1DAURi0EotPCI4C8ZEGKf-NkB5QClSp1A2vLsW-mZpJ4ajuMZsWr4zAzZQWyLFtX59xv8SH0ipJLShryjhBeS8noJSOsjJpyaPsEragkrFKKNE_RamGqBTpD5yn9IIRIJdrn6Iyztnx5s0K_7gYHEZs1YJ-wwdGnDe6NzSHivlw_GQcPs8mAYYK43pdJNhvAbo5-WmNj5wxvcYKfEAHffPyEzeT-rEopWF88h3c-3-N0H2IuSdmPgHPAEQazTfACPevNkODl8b1A3z9ff7v6Wt3efbm5-nBbWUlorhphpZFCSKVa1YqOqE623BAma9WBEcy6WhEqmAJnasF7K7pWyIbRmgJnjF-g6rA37WA7d3ob_WjiXgfj9XG0KT_Qom44kYVv_8lvY3B_pZNIhagZVw0p7puDW8CHGVLWo08WhsFMEOakmRC0JqyRCyoPqI0hpQj9YxAleulZn3rWS8_62HPxXh8j5m4E92idii3A-wPgp1LjaHYhDk5nsx9C7KOZrE-a_z_jNwSFt54</recordid><startdate>20201002</startdate><enddate>20201002</enddate><creator>Kulmala, Katja A.</creator><creator>Björk, Jan</creator><creator>Andersson, Sara</creator><creator>Backman, Ann-Sofie</creator><creator>Eberhardson, Michael</creator><creator>Bresso, Francesca</creator><creator>Hedin, Charlotte R. H.</creator><general>Taylor & Francis</general><scope>0YH</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>ADTPV</scope><scope>AOWAS</scope><scope>D8T</scope><scope>ZZAVC</scope><orcidid>https://orcid.org/0000-0002-4921-8516</orcidid><orcidid>https://orcid.org/0000-0002-8888-0529</orcidid></search><sort><creationdate>20201002</creationdate><title>Older age is a risk factor for inadequate energy intake during acute, severe IBD and is associated with shorter time to relapse</title><author>Kulmala, Katja A. ; Björk, Jan ; Andersson, Sara ; Backman, Ann-Sofie ; Eberhardson, Michael ; Bresso, Francesca ; Hedin, Charlotte R. H.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c501t-84c5a5445779794b07b593a02567bea42cd6701427eda643fc4b94582161e3223</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Gastroenterologi</topic><topic>IBD in elderly population</topic><topic>Klinisk medicin</topic><topic>Medicin och hälsovetenskap</topic><topic>Nutrition</topic><topic>real world data</topic><topic>severe flare of IBD</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kulmala, Katja A.</creatorcontrib><creatorcontrib>Björk, Jan</creatorcontrib><creatorcontrib>Andersson, Sara</creatorcontrib><creatorcontrib>Backman, Ann-Sofie</creatorcontrib><creatorcontrib>Eberhardson, Michael</creatorcontrib><creatorcontrib>Bresso, Francesca</creatorcontrib><creatorcontrib>Hedin, Charlotte R. H.</creatorcontrib><collection>Taylor & Francis Open Access</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>SwePub</collection><collection>SwePub Articles</collection><collection>SWEPUB Freely available online</collection><collection>SwePub Articles full text</collection><jtitle>Scandinavian journal of gastroenterology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kulmala, Katja A.</au><au>Björk, Jan</au><au>Andersson, Sara</au><au>Backman, Ann-Sofie</au><au>Eberhardson, Michael</au><au>Bresso, Francesca</au><au>Hedin, Charlotte R. H.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Older age is a risk factor for inadequate energy intake during acute, severe IBD and is associated with shorter time to relapse</atitle><jtitle>Scandinavian journal of gastroenterology</jtitle><addtitle>Scand J Gastroenterol</addtitle><date>2020-10-02</date><risdate>2020</risdate><volume>55</volume><issue>10</issue><spage>1185</spage><epage>1192</epage><pages>1185-1192</pages><issn>0036-5521</issn><issn>1502-7708</issn><eissn>1502-7708</eissn><abstract><![CDATA[Effects of nutritional intake on inflammatory bowel disease (IBD) flare resolution are unknown. We hypothesised that nutritional factors during hospitalisation for acute severe IBD are associated with risk of subsequent relapse. We also studied risk factors for inadequate energy intake.
Patients admitted to the Karolinska Hospital Gastroenterology ward with IBD flare during 2015-2016 were retrospectively identified. In total, 91 patients were included. Data on nutrition, disease factors, inflammatory markers, and daily energy requirement were extracted. Requirement of new systemic steroid prescription, intensification of biological therapy, readmission, surgery, and calprotectin level were individually used as proxies for disease relapse. Follow-up was one year after discharge. Adjustments for age and sex were made where appropriate.
Overall, 19%, 31%, and 45% of patients had days with energy intake <30, <50, and <70% of calculated requirement. Older age was associated with a higher number of days with energy intake <30, <50, and <70% of calculated requirement (regression coefficient 0.03, 0.04, 0.06 respectively, p = .012, .017, .008). The number of days with energy intake <30 and <70% of the calculated requirement and the length of the hospitalisation were associated with shorter time to new steroid prescription (hazard ratio 1.3, 1.1, 1.04 respectively, p = .016, .034, .011). CRP and calprotectin were not associated with relapse.
Older age is a predictor of inadequate energy intake during hospitalisation for acute severe IBD. Inadequate energy intake adjusted for age and sex during IBD flare was better predictor of time to the next steroid-requiring relapse than inflammatory markers.]]></abstract><cop>England</cop><pub>Taylor & Francis</pub><pmid>32905738</pmid><doi>10.1080/00365521.2020.1818119</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0002-4921-8516</orcidid><orcidid>https://orcid.org/0000-0002-8888-0529</orcidid><oa>free_for_read</oa></addata></record> |
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subjects | Gastroenterologi IBD in elderly population Klinisk medicin Medicin och hälsovetenskap Nutrition real world data severe flare of IBD |
title | Older age is a risk factor for inadequate energy intake during acute, severe IBD and is associated with shorter time to relapse |
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