Manganese(II) Texaphyrin: A Paramagnetic Photoacoustic Contrast Agent Activated by Near-IR Light

The NIR absorptivity of the metallotexaphyrin derivatives MMn, MGd, and MLu for photoacoustic (PA)-based imaging is explored in this study. All three complexes demonstrated excellent photostabilities; however, MMn provided the greatest PA signal intensities in both doubly distilled water and RAW 264...

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Bibliographic Details
Published in:Journal of the American Chemical Society 2020-09, Vol.142 (38), p.16156-16160
Main Authors: Ren, Yaguang, Sedgwick, Adam C, Chen, Jingqin, Thiabaud, Gregory, Chau, Calvin V, An, Jusung, Arambula, Jonathan F, He, Xiao-Peng, Kim, Jong Seung, Sessler, Jonathan L, Liu, Chengbo
Format: Article
Language:English
Subjects:
Animals
Cell Line, Tumor
Contrast Media - chemistry
Humans
Infrared Rays
Magnetic Resonance Imaging
Male
Manganese - chemistry
Mice
Mice, Nude
Molecular Structure
Neoplasms, Experimental - diagnostic imaging
Photoacoustic Techniques
Porphyrins - chemistry
Prostatic Neoplasms - diagnostic imaging
RAW 264.7 Cells
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Summary:The NIR absorptivity of the metallotexaphyrin derivatives MMn, MGd, and MLu for photoacoustic (PA)-based imaging is explored in this study. All three complexes demonstrated excellent photostabilities; however, MMn provided the greatest PA signal intensities in both doubly distilled water and RAW 264.7 cells. In vivo experiments using a prostate tumor mouse model were performed. MMn displayed no adverse toxicity to major organs as inferred from hematoxylin and eosin (H&E) staining and cell blood count testing. MMn also allowed for PA-based imaging of tumors with excellent in vivo stability to provide 3D tumor diagnostic information. Based on the present findings and previous magnetic resonance imaging (MRI) studies, we believe MMn may have a role to play either as a stand-alone PA contrast agent or as a single molecule dual modal (PA and MR) imaging agent for tumor diagnosis.
ISSN:0002-7863
1520-5126
DOI:10.1021/jacs.0c04387