Naringenin and naringin in cardiovascular disease prevention: A preclinical review

Cardiovascular disease is an important cause for morbidity and mortality worldwide. Flavonoids, such as naringin, and naringenin are important natural phytochemicals in the treatment or prevention of various disorders such as obesity, cardiac diseases, diabetes, and metabolic syndrome. Naringin and...

Full description

Saved in:
Bibliographic Details
Published in:European journal of pharmacology 2020-11, Vol.887, p.173535-173535, Article 173535
Main Authors: Heidary Moghaddam, Reza, Samimi, Zeinab, Moradi, Seyed Zachariah, Little, Peter J., Xu, Suowen, Farzaei, Mohammad Hosein
Format: Article
Language:English
Subjects:
439246
442428
Animals
Anti-Inflammatory Agents - therapeutic use
Anti-Oxidative
Antioxidants - therapeutic use
Cardiotonic Agents - therapeutic use
Cardiovascular disease
Cardiovascular Diseases - diagnosis
Cardiovascular Diseases - metabolism
Cardiovascular Diseases - prevention & control
Chemical compounds: naringin (PubChem CID
Flavanones - therapeutic use
Humans
Narigenin (PubChem CID
Naringenin
Naringin
Natural phytochemicals
Vasculature
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Cardiovascular disease is an important cause for morbidity and mortality worldwide. Flavonoids, such as naringin, and naringenin are important natural phytochemicals in the treatment or prevention of various disorders such as obesity, cardiac diseases, diabetes, and metabolic syndrome. Naringin and naringenin have significant therapeutic potential in several diseases through anti-oxidative, anti-inflammatory, and anti-apoptotic actions; these flavonoids play a protective role in human pathophysiology. In this review, based on the latest evidence, we present a summary of the impact of naringin, and naringenin on cardiovascular disease, and analyze and discuss the basic roles of naringin and naringenin and their mechanisms of actions in cardiovascular disease and other vascular dysfunction. The data collected in this review may serve as a comprehensive reference for the effects of naringin, and naringenin in cardiovascular disease, which may be beneficial for further research and for the design of naringin and naringenin analogs as new therapeutic options for cardiovascular diseases.
ISSN:0014-2999
1879-0712
DOI:10.1016/j.ejphar.2020.173535