Mitochondrial DNA damage in calf skeletal muscle and walking performance in people with peripheral artery disease

Peripheral artery disease (PAD) is associated with mitochondrial dysfunction in calf skeletal muscle and a greater abundance of mitochondrial DNA (mtDNA) heteroplasmy. However, it is unknown whether calf skeletal muscle mtDNA of PAD participants harbors a greater abundance of mitochondrial DNA 4977-...

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Bibliographic Details
Published in:Free radical biology & medicine 2020-11, Vol.160, p.680-689
Main Authors: Saini, Sunil K., McDermott, Mary M., Picca, Anna, Li, Lingyu, Wohlgemuth, Stephanie E., Kosmac, Kate, Peterson, Charlotte A., Tian, Lu, Ferrucci, Luigi, Guralnik, Jack M., Sufit, Robert L., Leeuwenburgh, Christiaan
Format: Article
Language:English
Subjects:
Ischemia-reperfusion
mtDNA copy number
mtDNA deletion
mtDNA heteroplasmy
mtDNA mutations
Oxidative stress
Peripheral artery disease (PAD)
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Summary:Peripheral artery disease (PAD) is associated with mitochondrial dysfunction in calf skeletal muscle and a greater abundance of mitochondrial DNA (mtDNA) heteroplasmy. However, it is unknown whether calf skeletal muscle mtDNA of PAD participants harbors a greater abundance of mitochondrial DNA 4977-bp common deletion (mtDNA4977), strand breaks and oxidative damage (i.e., oxidized purines) compared to non-PAD participants and whether these mtDNA abnormalities are associated with poor walking performance in participants with PAD. Calf muscle biopsies were obtained from 50 PAD participants (ankle-brachial index (ABI) 
ISSN:0891-5849
1873-4596
DOI:10.1016/j.freeradbiomed.2020.09.004