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Case report on 5-fluorouracil induced cerebrovascular accident
Introduction 5-Fluorouracil is an antineoplastic agent generally used to treat various types of solid tumors. The common adverse drug reaction associated with 5-fluorouracil are myelosuppression, mucositis, diarrhea, and hand-foot syndrome. Neurological side effects such as headache, dizziness, conv...
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| Published in: | Journal of oncology pharmacy practice 2021-06, Vol.27 (4), p.1016-1019 |
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| container_end_page | 1019 |
| container_issue | 4 |
| container_start_page | 1016 |
| container_title | Journal of oncology pharmacy practice |
| container_volume | 27 |
| creator | Karthikeyan, Kavya Babu, Christy M Shaji, Shintu Ashok, Ashwin M Madhu, CS |
| description | Introduction
5-Fluorouracil is an antineoplastic agent generally used to treat various types of solid tumors. The common adverse drug reaction associated with 5-fluorouracil are myelosuppression, mucositis, diarrhea, and hand-foot syndrome. Neurological side effects such as headache, dizziness, convulsion, encephalopathy, and acute cerebellar syndrome are rare in nature.
Case presentation
We report a case of 5-fluorouracil induced cerebrovascular accident (CVA) in a patient with no risk factors for CVA before chemotherapy. A 37 years old female patient diagnosed with carcinoma rectum underwent six cycles of chemotherapy with 5- fluorouracil- calcium leucovorin- irinotecan (FOLFIRI regimen). After completing the last cycle, she developed headache, vomiting, and facial deviation along with high blood pressure (260/160 mmHg). MRI brain was done, and it revealed acute non-hemorrhagic lacunar infarct in the left half of pons. 5-fluorouracil induced CVA was suspected and was managed with dual antiplatelet, statin, and antihypertensives.
Conclusion
The clinicians and clinical pharmacists must be aware about the potential of 5-FU to induce rare side effects such as CVA even in low risk patients in order to avoid permanent harm to the patient |
| doi_str_mv | 10.1177/1078155220954900 |
| format | article |
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5-Fluorouracil is an antineoplastic agent generally used to treat various types of solid tumors. The common adverse drug reaction associated with 5-fluorouracil are myelosuppression, mucositis, diarrhea, and hand-foot syndrome. Neurological side effects such as headache, dizziness, convulsion, encephalopathy, and acute cerebellar syndrome are rare in nature.
Case presentation
We report a case of 5-fluorouracil induced cerebrovascular accident (CVA) in a patient with no risk factors for CVA before chemotherapy. A 37 years old female patient diagnosed with carcinoma rectum underwent six cycles of chemotherapy with 5- fluorouracil- calcium leucovorin- irinotecan (FOLFIRI regimen). After completing the last cycle, she developed headache, vomiting, and facial deviation along with high blood pressure (260/160 mmHg). MRI brain was done, and it revealed acute non-hemorrhagic lacunar infarct in the left half of pons. 5-fluorouracil induced CVA was suspected and was managed with dual antiplatelet, statin, and antihypertensives.
Conclusion
The clinicians and clinical pharmacists must be aware about the potential of 5-FU to induce rare side effects such as CVA even in low risk patients in order to avoid permanent harm to the patient</description><identifier>ISSN: 1078-1552</identifier><identifier>EISSN: 1477-092X</identifier><identifier>DOI: 10.1177/1078155220954900</identifier><language>eng</language><publisher>London, England: SAGE Publications</publisher><subject>5-Fluorouracil ; Antihypertensives ; Blood pressure ; Calcium ; Case reports ; Cerebellum ; Chemotherapy ; Diarrhea ; Encephalopathy ; Headache ; Hemorrhage ; Hypertension ; Irinotecan ; Magnetic resonance imaging ; Mucositis ; Myelosuppression ; Pharmacists ; Pons ; Rectum ; Risk factors ; Risk groups ; Side effects ; Solid tumors ; Stroke ; Vomiting</subject><ispartof>Journal of oncology pharmacy practice, 2021-06, Vol.27 (4), p.1016-1019</ispartof><rights>The Author(s) 2020</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c342t-42033cf021bec352d1194ceb65db55b9f07149917618c9e8d2dad58e5a706b653</citedby><cites>FETCH-LOGICAL-c342t-42033cf021bec352d1194ceb65db55b9f07149917618c9e8d2dad58e5a706b653</cites><orcidid>0000-0002-1950-8280</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925,79236</link.rule.ids></links><search><creatorcontrib>Karthikeyan, Kavya</creatorcontrib><creatorcontrib>Babu, Christy M</creatorcontrib><creatorcontrib>Shaji, Shintu</creatorcontrib><creatorcontrib>Ashok, Ashwin M</creatorcontrib><creatorcontrib>Madhu, CS</creatorcontrib><title>Case report on 5-fluorouracil induced cerebrovascular accident</title><title>Journal of oncology pharmacy practice</title><description>Introduction
5-Fluorouracil is an antineoplastic agent generally used to treat various types of solid tumors. The common adverse drug reaction associated with 5-fluorouracil are myelosuppression, mucositis, diarrhea, and hand-foot syndrome. Neurological side effects such as headache, dizziness, convulsion, encephalopathy, and acute cerebellar syndrome are rare in nature.
Case presentation
We report a case of 5-fluorouracil induced cerebrovascular accident (CVA) in a patient with no risk factors for CVA before chemotherapy. A 37 years old female patient diagnosed with carcinoma rectum underwent six cycles of chemotherapy with 5- fluorouracil- calcium leucovorin- irinotecan (FOLFIRI regimen). After completing the last cycle, she developed headache, vomiting, and facial deviation along with high blood pressure (260/160 mmHg). MRI brain was done, and it revealed acute non-hemorrhagic lacunar infarct in the left half of pons. 5-fluorouracil induced CVA was suspected and was managed with dual antiplatelet, statin, and antihypertensives.
Conclusion
The clinicians and clinical pharmacists must be aware about the potential of 5-FU to induce rare side effects such as CVA even in low risk patients in order to avoid permanent harm to the patient</description><subject>5-Fluorouracil</subject><subject>Antihypertensives</subject><subject>Blood pressure</subject><subject>Calcium</subject><subject>Case reports</subject><subject>Cerebellum</subject><subject>Chemotherapy</subject><subject>Diarrhea</subject><subject>Encephalopathy</subject><subject>Headache</subject><subject>Hemorrhage</subject><subject>Hypertension</subject><subject>Irinotecan</subject><subject>Magnetic resonance imaging</subject><subject>Mucositis</subject><subject>Myelosuppression</subject><subject>Pharmacists</subject><subject>Pons</subject><subject>Rectum</subject><subject>Risk factors</subject><subject>Risk groups</subject><subject>Side effects</subject><subject>Solid tumors</subject><subject>Stroke</subject><subject>Vomiting</subject><issn>1078-1552</issn><issn>1477-092X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><recordid>eNp1kEFLxDAQhYMouK7ePRa8eKnOpEmTXARZXBUWvCh4K2kylS7dZk1awX9vlxWEBU8z8L73mHmMXSLcICp1i6A0Ssk5GCkMwBGboVAqB8Pfj6d9kvOdfsrOUloDgFZcz9jdwibKIm1DHLLQZzJvujHEMEbr2i5rez868pmjSHUMXza5sbMxs861nvrhnJ00tkt08Tvn7G358Lp4ylcvj8-L-1XuCsGHXHAoCtcAx5pcIblHNMJRXUpfS1mbBhQKY1CVqJ0h7bm3XmqSVkE5UcWcXe9ztzF8jpSGatMmR11newpjqrgQWCIIvUOvDtD19E0_XVdxWRgtDEc-UbCnXAwpRWqqbWw3Nn5XCNWu0Oqw0MmS7y3JftBf6L_8D54Kc1M</recordid><startdate>202106</startdate><enddate>202106</enddate><creator>Karthikeyan, Kavya</creator><creator>Babu, Christy M</creator><creator>Shaji, Shintu</creator><creator>Ashok, Ashwin M</creator><creator>Madhu, CS</creator><general>SAGE Publications</general><general>Sage Publications Ltd</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7TO</scope><scope>H94</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-1950-8280</orcidid></search><sort><creationdate>202106</creationdate><title>Case report on 5-fluorouracil induced cerebrovascular accident</title><author>Karthikeyan, Kavya ; Babu, Christy M ; Shaji, Shintu ; Ashok, Ashwin M ; Madhu, CS</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c342t-42033cf021bec352d1194ceb65db55b9f07149917618c9e8d2dad58e5a706b653</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>5-Fluorouracil</topic><topic>Antihypertensives</topic><topic>Blood pressure</topic><topic>Calcium</topic><topic>Case reports</topic><topic>Cerebellum</topic><topic>Chemotherapy</topic><topic>Diarrhea</topic><topic>Encephalopathy</topic><topic>Headache</topic><topic>Hemorrhage</topic><topic>Hypertension</topic><topic>Irinotecan</topic><topic>Magnetic resonance imaging</topic><topic>Mucositis</topic><topic>Myelosuppression</topic><topic>Pharmacists</topic><topic>Pons</topic><topic>Rectum</topic><topic>Risk factors</topic><topic>Risk groups</topic><topic>Side effects</topic><topic>Solid tumors</topic><topic>Stroke</topic><topic>Vomiting</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Karthikeyan, Kavya</creatorcontrib><creatorcontrib>Babu, Christy M</creatorcontrib><creatorcontrib>Shaji, Shintu</creatorcontrib><creatorcontrib>Ashok, Ashwin M</creatorcontrib><creatorcontrib>Madhu, CS</creatorcontrib><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of oncology pharmacy practice</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Karthikeyan, Kavya</au><au>Babu, Christy M</au><au>Shaji, Shintu</au><au>Ashok, Ashwin M</au><au>Madhu, CS</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Case report on 5-fluorouracil induced cerebrovascular accident</atitle><jtitle>Journal of oncology pharmacy practice</jtitle><date>2021-06</date><risdate>2021</risdate><volume>27</volume><issue>4</issue><spage>1016</spage><epage>1019</epage><pages>1016-1019</pages><issn>1078-1552</issn><eissn>1477-092X</eissn><abstract>Introduction
5-Fluorouracil is an antineoplastic agent generally used to treat various types of solid tumors. The common adverse drug reaction associated with 5-fluorouracil are myelosuppression, mucositis, diarrhea, and hand-foot syndrome. Neurological side effects such as headache, dizziness, convulsion, encephalopathy, and acute cerebellar syndrome are rare in nature.
Case presentation
We report a case of 5-fluorouracil induced cerebrovascular accident (CVA) in a patient with no risk factors for CVA before chemotherapy. A 37 years old female patient diagnosed with carcinoma rectum underwent six cycles of chemotherapy with 5- fluorouracil- calcium leucovorin- irinotecan (FOLFIRI regimen). After completing the last cycle, she developed headache, vomiting, and facial deviation along with high blood pressure (260/160 mmHg). MRI brain was done, and it revealed acute non-hemorrhagic lacunar infarct in the left half of pons. 5-fluorouracil induced CVA was suspected and was managed with dual antiplatelet, statin, and antihypertensives.
Conclusion
The clinicians and clinical pharmacists must be aware about the potential of 5-FU to induce rare side effects such as CVA even in low risk patients in order to avoid permanent harm to the patient</abstract><cop>London, England</cop><pub>SAGE Publications</pub><doi>10.1177/1078155220954900</doi><tpages>4</tpages><orcidid>https://orcid.org/0000-0002-1950-8280</orcidid></addata></record> |
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| ispartof | Journal of oncology pharmacy practice, 2021-06, Vol.27 (4), p.1016-1019 |
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| subjects | 5-Fluorouracil Antihypertensives Blood pressure Calcium Case reports Cerebellum Chemotherapy Diarrhea Encephalopathy Headache Hemorrhage Hypertension Irinotecan Magnetic resonance imaging Mucositis Myelosuppression Pharmacists Pons Rectum Risk factors Risk groups Side effects Solid tumors Stroke Vomiting |
| title | Case report on 5-fluorouracil induced cerebrovascular accident |
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