Antigen-Specific Activation of Blood Lymphocytes in Mice Immunized with Brucella abortus 19 BA

We studied the expression of activation markers CD25 and CD69 by blood lymphocytes in white mice vaccinated with Brucella abortus 19 BA in antigen-specific tests in vitro . During incubation of blood lymphocytes with brucellosis polysaccharide-protein antigen, a statistically significant increase in...

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Bibliographic Details
Published in:Bulletin of experimental biology and medicine 2020-08, Vol.169 (4), p.483-485
Main Authors: Voitkova, V. V., Korytov, K. M., Dubrovina, V. I., Barannikova, N. L., Pyatidesyatnikova, A. B., Shkaruba, T. T., Balakhonov, S. V.
Format: Article
Language:English
Subjects:
Analysis
Antigens
B cells
Biomedical and Life Sciences
Biomedicine
Cell Biology
Internal Medicine
Laboratory Medicine
Pathology
T cells
Vaccination
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Summary:We studied the expression of activation markers CD25 and CD69 by blood lymphocytes in white mice vaccinated with Brucella abortus 19 BA in antigen-specific tests in vitro . During incubation of blood lymphocytes with brucellosis polysaccharide-protein antigen, a statistically significant increase in the expression of CD25 by B cells and CD69 by T cells was observed; brucellin increased the expression of CD25 by B and T cells. Comparative analysis of the action of antigen preparations B. abortus showed that only brucellin has antigen-specific activity against CD19 + CD25 + cells. The used method can be considered as a promising test for evaluation of the effectiveness of brucellosis immunoprophylaxis, which substantiates the need for further research.
ISSN:0007-4888
1573-8221
DOI:10.1007/s10517-020-04914-6