Susceptibility of Pseudomonas aeruginosa veterinary isolates to Pbunavirus PB1‐like phages

In recent years, antimicrobial‐resistant Pseudomonas aeruginosa strains have increased in the veterinary field. Therefore, phage therapy has received significant attention as an approach for overcoming antimicrobial resistance. In this context, we isolated and characterized four Pseudomonas bacterio...

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Bibliographic Details
Published in:Microbiology and immunology 2020-11, Vol.64 (11), p.778-782
Main Authors: Fujiki, Jumpei, Furusawa, Takaaki, Munby, Montgomery, Kawaguchi, Chika, Matsuda, Yumie, Shiokura, Yusei, Nakamura, Keisuke, Nakamura, Tomohiro, Sasaki, Michihito, Usui, Masaru, Iwasaki, Tomohito, Gondaira, Satoshi, Higuchi, Hidetoshi, Sawa, Hirofumi, Tamura, Yutaka, Iwano, Hidetomo
Format: Article
Language:English
Subjects:
Antimicrobial agents
Antimicrobial resistance
Bacteriophage
PB1‐like phage
Pbunavirus
phage therapy
Phages
Phylogeny
Pseudomonas aeruginosa
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Summary:In recent years, antimicrobial‐resistant Pseudomonas aeruginosa strains have increased in the veterinary field. Therefore, phage therapy has received significant attention as an approach for overcoming antimicrobial resistance. In this context, we isolated and characterized four Pseudomonas bacteriophages. Phylogenetic analysis showed that the isolated phages are novel Myoviridae Pbunavirus PB1‐like phages with ØR12 belonging to a different clade compared with the other three. These phages had distinct lytic activity against 22 P. aeruginosa veterinary isolates. The phage cocktail composed from the PB1‐like phages clearly inhibited the occurrence of the phage‐resistant variant, suggesting that these phages could be useful in phage therapy.
ISSN:0385-5600
1348-0421
DOI:10.1111/1348-0421.12846