Cognitive task-related functional connectivity alterations in temporal lobe epilepsy

• Published in: Epilepsy & behavior 2020-11, Vol.112, p.107409-107409, Article 107409
• Main Authors: Strýček, Ondřej, Lamoš, Martin, Klimeš, Petr, Rektor, Ivan
• Format: Article
• Language: English
• Subjects: Brain Mapping; Cognition; Cognitive network; Epilepsy, Temporal Lobe - complications; Functional connectivity; Functional Laterality; High-density EEG; Humans; Magnetic Resonance Imaging; Temporal lobe epilepsy
• ISSN: 1525-5050; 1525-5069
• DOI: 10.1016/j.yebeh.2020.107409

We investigated cognitive task-related functional connectivity (FC) in patients with temporal lobe epilepsy (TLE). Using a visual three-stimulus paradigm (VTSP), we studied cognitive large-scale networks and the impact of TLE on connectivity outside the temporal lobe. High-density electroencephalography (EEG) was recorded during the paradigm from nineteen patients with epilepsy with hippocampal sclerosis (HS) and ten healthy controls (HCs). Scalp data were reconstructed into the source space, and FC was computed. Correlating with the neuropsychological data, possible compensatory mechanisms were investigated. Significant changes were found in the FC of regions outside the epileptogenic network, particularly in the attentional network. These changes were more widespread in left TLE (LTLE). There were no significant differences in task performance (accuracy, time response) in comparison with HCs, implying that there must be some mechanism reducing the impact of connectivity changes on brain functions. When correlated with neuropsychological data, we found stronger compensatory mechanisms in right TLE (RTLE). Our findings confirm the hypothesis that LTLE is the more pervasive form of the disease. Even though the network alterations in TLE are severe, some mechanisms reduce the impact of epilepsy on cognitive functions; these mechanisms are more potent in RTLE. We also suggest that there are maladaptive mechanisms in LTLE. •Cognitive functional connectivity is changed significantly outside epileptogenic network.•Functional connectivity is more altered in the left temporal lobe epilepsy.•The most potent compensatory mechanisms are in the right temporal lobe epilepsy.