Association of non-HDL-C/HDL-C ratio and its dynamic changes with incident type 2 diabetes mellitus: The Rural Chinese Cohort Study

• Published in: Journal of diabetes and its complications 2020-12, Vol.34 (12), p.107712-107712, Article 107712
• Main Authors: Han, Minghui, Li, Quanman, Qie, Ranran, Guo, Chunmei, Zhou, Qionggui, Tian, Gang, Huang, Shengbing, Wu, Xiaoyan, Ren, Yongcheng, Zhao, Yang, Liu, Dechen, Zhang, Dongdong, Liu, Leilei, Liu, Feiyan, Chen, Xu, Cheng, Cheng, Li, Yang, Yang, Xingjin, Feng, Yifei, Liu, Yu, Li, Honghui, Sun, Xizhuo, Qin, Pei, Chen, Qing, Zhang, Ming, Hu, Dongsheng, Lu, Jie
• Format: Article
• Language: English
• Subjects: Age; Alcohol; Alzheimer's disease; Body mass index; Cardiovascular disease; Cholesterol; Cohort analysis; Diabetes; Dynamic change; Family medical history; Laboratories; Lipids; Marital status; Non-HDL-C/HDL-C ratio; Prospective cohort study; Public health; Questionnaires; Rural areas; Smoking; Type 2 diabetes mellitus
• ISSN: 1056-8727; 1873-460X
• DOI: 10.1016/j.jdiacomp.2020.107712

We aimed to evaluate the association of the ratio of non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol (non-HDL-C/HDL-C) and its dynamic changes with incident type 2 diabetes mellitus (T2DM). A total of 11,487 nondiabetic participants ≥18 years old in rural China were recruited in 2007–2008 and followed up in 2013–2014. A Cox proportional-hazards model was used to assess the risk of incident T2DM by quartiles of baseline non-HDL-C/HDL-C ratio and dynamic absolute and relative changes in non-HDL-C/HDL-C ratio, estimating hazard ratios (HRs) and 95% confidence intervals (CIs). Risk of incident T2DM was increased with quartiles 2, 3, and 4 versus quartile 1 of baseline non-HDL-C/HDL-C ratio (HR 1.46 [95% CI 1.08–1.98], 1.51 [1.12–2.03], and 2.16 [1.62–2.88], Ptrend