Juvenile lupus and serum vitamin D levels: A cross-sectional study

Background Juvenile systemic lupus erythematosus (JSLE) is usually associated with vitamin D deficiency and low bone mineral density. Objectives To evaluate serum levels of 25-OH vitamin D in JSLE patients and to correlate these findings with disease activity and bone density. Methods This study was...

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Bibliographic Details
Published in:Lupus 2020-11, Vol.29 (13), p.1752-1758
Main Authors: Tabra, Samar abd Alhamed, Abdelnabi, Hend Hassan, Darwish, Nivine Fathi Mahmoud, El-Barbary, Amal Mohammed, AbdelGhafar, Muhammad Tarek, Abu-Zaid, Mohammed Hassan
Format: Article
Language:English
Subjects:
Anti-DNA antibodies
Bone density
Bone mineral density
Creatinine
Cross-sectional studies
Glomerular filtration rate
Lupus
Parathyroid hormone
Proteinuria
Serum levels
Systemic lupus erythematosus
Vitamin D
Vitamin deficiency
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Summary:Background Juvenile systemic lupus erythematosus (JSLE) is usually associated with vitamin D deficiency and low bone mineral density. Objectives To evaluate serum levels of 25-OH vitamin D in JSLE patients and to correlate these findings with disease activity and bone density. Methods This study was conducted on 100 patients with JSLE and 100 healthy children as controls. Disease duration and SLEDAI for disease activity were evaluated. CBC, anti-dsDNA, C3,C4,24hr urinary proteins, creatinine, estimated glomerular filtration rate(e-GFR),Ca,P,PTH, 25 (OH) D levels, and bone mineral density(BMD)Z score were measured. Results There were significant differences in mean 25(OH)D concentration between patients group (19.37 ± 9.72 ng/ml) and controls 35.90 ± 9.66 ng/ml(p 
ISSN:0961-2033
1477-0962
DOI:10.1177/0961203320957721