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Nano-hesperetin enhances the functional recovery and endogenous remyelination of the optic pathway in focal demyelination model
•Nano-Hst reduces the latency of VEP waves in lysolecithin-induced demyelination model.•Nano-Hst decreases the levels of activated microglia and reactive astrocytes in focal demyelination model of optic chiasm.•Nano-Hst enhances the endogenous remyelination of optic chiasm in lysolecithin–induced de...
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Published in: | Brain research bulletin 2020-11, Vol.164, p.392-399 |
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description | •Nano-Hst reduces the latency of VEP waves in lysolecithin-induced demyelination model.•Nano-Hst decreases the levels of activated microglia and reactive astrocytes in focal demyelination model of optic chiasm.•Nano-Hst enhances the endogenous remyelination of optic chiasm in lysolecithin–induced demyelination model.
Our recent report demonstrated that hesperetin (Hst) as a citrus flavonoid, significantly reduces the levels of demyelination in optic chiasm of rats. Previous evidence also indicated that nano-hesperetin (nano-Hst) possesses beneficial impacts in experimental models of Alzheimer's disease and autism. In this study, the effects of nano-Hst on latency of visual signals, demyelination levels, glial activation, and expression of Olig2 and MBP were evaluated in lysolecithin (LPC)-induced demyelination model. Focal demyelination was induced by injection of LPC (1%, 2 μL) into the rat optic chiasm. Animals received oral administration of nano-Hst at dose of 20 mg/kg for 14 or 21 days post LPC injection. Visual evoked potential (VEP) recording showed that nano-Hst reduces the latency of visual signals and ameliorates the extent of demyelination areas and glial activation. Expression levels of the Olig2 and MBP were also significantly increased in nano-Hst treated rats. Overall, our data suggest that nano-Hst reduces the latency of visual signals through its protective effects on myelin sheath, amelioration of glial activation, and enhancement of endogenous remyelination. |
doi_str_mv | 10.1016/j.brainresbull.2020.09.006 |
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Our recent report demonstrated that hesperetin (Hst) as a citrus flavonoid, significantly reduces the levels of demyelination in optic chiasm of rats. Previous evidence also indicated that nano-hesperetin (nano-Hst) possesses beneficial impacts in experimental models of Alzheimer's disease and autism. In this study, the effects of nano-Hst on latency of visual signals, demyelination levels, glial activation, and expression of Olig2 and MBP were evaluated in lysolecithin (LPC)-induced demyelination model. Focal demyelination was induced by injection of LPC (1%, 2 μL) into the rat optic chiasm. Animals received oral administration of nano-Hst at dose of 20 mg/kg for 14 or 21 days post LPC injection. Visual evoked potential (VEP) recording showed that nano-Hst reduces the latency of visual signals and ameliorates the extent of demyelination areas and glial activation. Expression levels of the Olig2 and MBP were also significantly increased in nano-Hst treated rats. Overall, our data suggest that nano-Hst reduces the latency of visual signals through its protective effects on myelin sheath, amelioration of glial activation, and enhancement of endogenous remyelination.</description><identifier>ISSN: 0361-9230</identifier><identifier>EISSN: 1873-2747</identifier><identifier>DOI: 10.1016/j.brainresbull.2020.09.006</identifier><identifier>PMID: 32926949</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Demyelination ; Hesperetin ; Lysolecithin ; Nano-hesperetin ; Optic chiasm</subject><ispartof>Brain research bulletin, 2020-11, Vol.164, p.392-399</ispartof><rights>2020 Elsevier Inc.</rights><rights>Copyright © 2020 Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c446t-b96d50a2af36fdca5f7ff53bc5049442c3aec14cc351ea821127963d72a41eed3</citedby><cites>FETCH-LOGICAL-c446t-b96d50a2af36fdca5f7ff53bc5049442c3aec14cc351ea821127963d72a41eed3</cites><orcidid>0000-0001-5802-2147 ; 0000-0002-5014-5166</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32926949$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Baradaran, Saeideh</creatorcontrib><creatorcontrib>Ghasemi-Kasman, Maryam</creatorcontrib><creatorcontrib>Moghaddam, Akbar Hajizadeh</creatorcontrib><title>Nano-hesperetin enhances the functional recovery and endogenous remyelination of the optic pathway in focal demyelination model</title><title>Brain research bulletin</title><addtitle>Brain Res Bull</addtitle><description>•Nano-Hst reduces the latency of VEP waves in lysolecithin-induced demyelination model.•Nano-Hst decreases the levels of activated microglia and reactive astrocytes in focal demyelination model of optic chiasm.•Nano-Hst enhances the endogenous remyelination of optic chiasm in lysolecithin–induced demyelination model.
Our recent report demonstrated that hesperetin (Hst) as a citrus flavonoid, significantly reduces the levels of demyelination in optic chiasm of rats. Previous evidence also indicated that nano-hesperetin (nano-Hst) possesses beneficial impacts in experimental models of Alzheimer's disease and autism. In this study, the effects of nano-Hst on latency of visual signals, demyelination levels, glial activation, and expression of Olig2 and MBP were evaluated in lysolecithin (LPC)-induced demyelination model. Focal demyelination was induced by injection of LPC (1%, 2 μL) into the rat optic chiasm. Animals received oral administration of nano-Hst at dose of 20 mg/kg for 14 or 21 days post LPC injection. Visual evoked potential (VEP) recording showed that nano-Hst reduces the latency of visual signals and ameliorates the extent of demyelination areas and glial activation. Expression levels of the Olig2 and MBP were also significantly increased in nano-Hst treated rats. Overall, our data suggest that nano-Hst reduces the latency of visual signals through its protective effects on myelin sheath, amelioration of glial activation, and enhancement of endogenous remyelination.</description><subject>Demyelination</subject><subject>Hesperetin</subject><subject>Lysolecithin</subject><subject>Nano-hesperetin</subject><subject>Optic chiasm</subject><issn>0361-9230</issn><issn>1873-2747</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><recordid>eNqNkU9P3DAQxa2qFWwpX6GKeuolqf_FWXOrKNBKqFzo2XLscderxA52QrWnfnW8LEX0xmmk0e-90byH0CeCG4KJ-LJt-qR9SJD7ZRgaiilusGwwFm_Qiqw7VtOOd2_RCjNBakkZPkbvc97iQqxbcYSOGZVUSC5X6O9PHWK9gTxBgtmHCsJGBwO5mjdQuSWY2ceghyqBifeQdpUOtkA2_oYQl1z24w4GH_Seq6J71MVp9qaa9Lz5o3dVcXXRFA_7HztGC8MH9M7pIcPp0zxBvy4vbs-_19c3Vz_Ov17XhnMx170UtsWaaseEs0a3rnOuZb1pMZecU8M0GMKNYS0BvaaE0E4KZjuqOQGw7AR9PvhOKd4tkGc1-mxgGHSA8oaixWTNWdeJgp4dUJNizgmcmpIfddopgtW-ALVVLwtQ-wIUlqrEW8Qfn-4s_Qj2Wfov8QJ8OwBQvr33kFQ2Hkri1peIZ2Wjf82dB-6moh0</recordid><startdate>202011</startdate><enddate>202011</enddate><creator>Baradaran, Saeideh</creator><creator>Ghasemi-Kasman, Maryam</creator><creator>Moghaddam, Akbar Hajizadeh</creator><general>Elsevier Inc</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-5802-2147</orcidid><orcidid>https://orcid.org/0000-0002-5014-5166</orcidid></search><sort><creationdate>202011</creationdate><title>Nano-hesperetin enhances the functional recovery and endogenous remyelination of the optic pathway in focal demyelination model</title><author>Baradaran, Saeideh ; Ghasemi-Kasman, Maryam ; Moghaddam, Akbar Hajizadeh</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c446t-b96d50a2af36fdca5f7ff53bc5049442c3aec14cc351ea821127963d72a41eed3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Demyelination</topic><topic>Hesperetin</topic><topic>Lysolecithin</topic><topic>Nano-hesperetin</topic><topic>Optic chiasm</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Baradaran, Saeideh</creatorcontrib><creatorcontrib>Ghasemi-Kasman, Maryam</creatorcontrib><creatorcontrib>Moghaddam, Akbar Hajizadeh</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Brain research bulletin</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Baradaran, Saeideh</au><au>Ghasemi-Kasman, Maryam</au><au>Moghaddam, Akbar Hajizadeh</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Nano-hesperetin enhances the functional recovery and endogenous remyelination of the optic pathway in focal demyelination model</atitle><jtitle>Brain research bulletin</jtitle><addtitle>Brain Res Bull</addtitle><date>2020-11</date><risdate>2020</risdate><volume>164</volume><spage>392</spage><epage>399</epage><pages>392-399</pages><issn>0361-9230</issn><eissn>1873-2747</eissn><abstract>•Nano-Hst reduces the latency of VEP waves in lysolecithin-induced demyelination model.•Nano-Hst decreases the levels of activated microglia and reactive astrocytes in focal demyelination model of optic chiasm.•Nano-Hst enhances the endogenous remyelination of optic chiasm in lysolecithin–induced demyelination model.
Our recent report demonstrated that hesperetin (Hst) as a citrus flavonoid, significantly reduces the levels of demyelination in optic chiasm of rats. Previous evidence also indicated that nano-hesperetin (nano-Hst) possesses beneficial impacts in experimental models of Alzheimer's disease and autism. In this study, the effects of nano-Hst on latency of visual signals, demyelination levels, glial activation, and expression of Olig2 and MBP were evaluated in lysolecithin (LPC)-induced demyelination model. Focal demyelination was induced by injection of LPC (1%, 2 μL) into the rat optic chiasm. Animals received oral administration of nano-Hst at dose of 20 mg/kg for 14 or 21 days post LPC injection. Visual evoked potential (VEP) recording showed that nano-Hst reduces the latency of visual signals and ameliorates the extent of demyelination areas and glial activation. Expression levels of the Olig2 and MBP were also significantly increased in nano-Hst treated rats. Overall, our data suggest that nano-Hst reduces the latency of visual signals through its protective effects on myelin sheath, amelioration of glial activation, and enhancement of endogenous remyelination.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>32926949</pmid><doi>10.1016/j.brainresbull.2020.09.006</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0001-5802-2147</orcidid><orcidid>https://orcid.org/0000-0002-5014-5166</orcidid></addata></record> |
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title | Nano-hesperetin enhances the functional recovery and endogenous remyelination of the optic pathway in focal demyelination model |
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