Natural products as potent inhibitors of hypoxia-inducible factor-1α in cancer therapy

Hypoxia is a prominent feature of tumors. Hypoxia-inducible factor-1α (HIF-1α), a major subunit of HIF-1, is overexpressed in hypoxic tumor tissues and activates the transcription of many oncogenes. Accumulating evidence has demonstrated that HIF-1α promotes tumor angiogenesis, metastasis, metabolis...

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Bibliographic Details
Published in:Chinese journal of natural medicines 2020-09, Vol.18 (9), p.696-703
Main Authors: ZHONG, Jin-Cheng, LI, Xiao-Bo, LYU, Wen-Yu, YE, Wen-Cai, ZHANG, Dong-Mei
Format: Article
Language:English
Subjects:
Anticancer treatment
Cancer
Hypoxia
Hypoxia-inducible factor-1α
Natural products
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Summary:Hypoxia is a prominent feature of tumors. Hypoxia-inducible factor-1α (HIF-1α), a major subunit of HIF-1, is overexpressed in hypoxic tumor tissues and activates the transcription of many oncogenes. Accumulating evidence has demonstrated that HIF-1α promotes tumor angiogenesis, metastasis, metabolism, and immune evasion. Natural products are an important source of antitumor drugs and numerous studies have highlighted the crucial role of these agents in modulating HIF-1α. The present review describes the role of HIF-1α in tumor progression, summarizes natural products used as HIF-1α inhibitors, and discusses the potential of developing natural products as HIF-1α inhibitors for the treatment of cancer.
ISSN:1875-5364
1875-5364
DOI:10.1016/S1875-5364(20)60008-5