Association between metabolic syndrome and gestational diabetes mellitus in women and their children: a systematic review and meta-analysis

Purpose The primary aim of this systematic review and meta-analysis was to determine the association between gestational diabetes mellitus (GDM) and metabolic syndrome (MetS) in women and children. Our secondary aim was to assess the development of MetS with respect to the elapsed time postpartum at...

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Bibliographic Details
Published in:Endocrine 2021-02, Vol.71 (2), p.310-320
Main Authors: Pathirana, Maleesa M., Lassi, Zohra S., Ali, Anna, Arstall, Margaret A., Roberts, Claire T., Andraweera, Prabha H.
Format: Article
Language:English
Subjects:
Children
Diabetes
Diabetes mellitus
Endocrinology
Gestational diabetes
Humanities and Social Sciences
Internal Medicine
Medicine
Medicine & Public Health
Meta- Analysis
Metabolic syndrome
multidisciplinary
Offspring
Postpartum
Pregnancy
Reviews
Science
Systematic review
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Summary:Purpose The primary aim of this systematic review and meta-analysis was to determine the association between gestational diabetes mellitus (GDM) and metabolic syndrome (MetS) in women and children. Our secondary aim was to assess the development of MetS with respect to the elapsed time postpartum at which MetS was diagnosed. Methods This review is registered with PROSPERO (CRD42020173319). PubMed, CINHAL, SCOPUS, and EMBASE databases were searched. Studies reporting on the rate of MetS in pregnant women with GDM, the rate of MetS in women with a history of GDM, and the rate of MetS in offspring exposed to GDM in utero compared to healthy controls were selected. Results We identified 588 articles from the literature search. Fifty-one studies were included in the review and of those 35 were included in the meta-analysis. Quantitative summary measures showed that women with a history of GDM had an increased risk of developing MetS compared to those without a history of GDM (RR 2.36, 95% CI 1.77–3.14, 29 studies, 13,390 participants; heterogeneity: χ 2 p  
ISSN:1355-008X
1559-0100
DOI:10.1007/s12020-020-02492-1