Severe scoliosis with an impaired pulmonary allograft function after pediatric unilateral lung transplantation

Left‐unilateral single‐lobe lung transplantation from a living donor was performed in a 4-year-old boy who suffered from severe respiratory failure caused by bronchiolitis obliterans (BO) as a result of graft versus host disease (GVHD) after peripheral blood stem cell transplantation (PBSCT). The pa...

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Bibliographic Details
Published in:General thoracic and cardiovascular surgery 2021-02, Vol.69 (2), p.375-378
Main Authors: Shiraishi, Takeshi, Yanagida, Haruhisa, Koga, Yuhki, Ohga, Shouichi, Fujita, Masaki, Hiratsuka, Masafumi, Miyahara, So, Waseda, Ryuichi, Sato, Toshihiko, Iwasaki, Akinori
Format: Article
Language:English
Subjects:
Allografts
Back surgery
Bronchiolitis Obliterans - etiology
Cardiac Surgery
Cardiology
Case Report
Child
Child, Preschool
Compliance
Graft versus host disease
Humans
Leukemia
Lung Transplantation - adverse effects
Lung transplants
Male
Medicine
Medicine & Public Health
Pediatrics
Physiology
Pneumonectomy
Scoliosis
Scoliosis - surgery
Spinal Fusion - adverse effects
Stem cell transplantation
Surgical Oncology
Thoracic Surgery
Treatment Outcome
Ventilation
Ventilators
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Summary:Left‐unilateral single‐lobe lung transplantation from a living donor was performed in a 4-year-old boy who suffered from severe respiratory failure caused by bronchiolitis obliterans (BO) as a result of graft versus host disease (GVHD) after peripheral blood stem cell transplantation (PBSCT). The patient grew well during his early childhood years, with an excellent lung allograft function. However, severe thoracic scoliosis occurred 7 years after lung transplantation, which ultimately resulted in compression of the lung allograft followed by severe respiratory dysfunction, and the patient became dependent on mechanical ventilation support. Posterior spinal fusion of Th2‐L3 with instrumentation and bone grafting was performed to correct scoliosis in the hope of recovering his thoracic capacity. The left thoracic volume was dramatically improved immediately after spinal fusion surgery, and the patient was ultimately weaned off of mechanical ventilation after a year of pulmonary rehabilitation.
ISSN:1863-6705
1863-6713
DOI:10.1007/s11748-020-01447-7