Volumetric brain magnetic resonance imaging analysis in children with obstructive sleep apnea

• Published in: International journal of pediatric otorhinolaryngology 2020-11, Vol.138, p.110369-110369, Article 110369
• Main Authors: Musso, Mary Frances, Lindsey, Hannah M., Wilde, Elisabeth A., Hunter, Jill V., Glaze, Daniel G., Goodrich-Hunsaker, Naomi J., Wu, Trevor C., Black, Garrett, Biekman, Brian, Zhang, Wei, Zhu, Huirong, Anand, Grace Shebha, Friedman, Ellen M.
• Format: Article
• Language: English
• Subjects: Brain Cortical Thickness; Brain volume; Case-Control Studies; Child; Female; Gray Matter - diagnostic imaging; Gray Matter - pathology; Humans; Magnetic Resonance Imaging; Male; MRI; Obstructive sleep apnea; Organ Size; Pediatric; Polysomnography; Prospective Studies; Sleep Apnea, Obstructive - diagnostic imaging; Sleep Apnea, Obstructive - pathology; White Matter - diagnostic imaging; White Matter - pathology
• ISSN: 0165-5876; 1872-8464
• DOI: 10.1016/j.ijporl.2020.110369

Pediatric Obstructive Sleep Apnea (OSA) is associated with neurocognitive deficits. Cerebral structural alterations in the frontal cortex, cerebellum, and hippocampus have been reported in adult OSA patients. These brain areas are important for executive functioning, motor regulation of breathing, and memory function, respectively. Corresponding evidence comparing cerebral structures in pediatric OSA patients is limited. The objective of this study is to investigate MRI differences in cortical thickness and cortical volume in children with and without OSA. Prospective, single institutional case-control study. Forty-five children were recruited at a pediatric tertiary care center (27 with OSA; mean age 9.9 ± 1.9 years, and 18 controls; mean age 10.5 ± 1.0 years). The OSA group underwent magnetic resonance imaging (MRI), polysomnography (PSG) and completed the Pediatric Daytime Sleepiness Scale (PDSS) and the Child's Sleep Habits Questionnaire (CSHQ). High-resolution T1-weighted MRI was utilized to examine cortical thickness and gray and white matter volume in children with OSA compared to a healthy group of demographically-comparable children without OSA selected from a pre-existing MRI dataset. Children with OSA showed multiple regions of cortical thinning primarily in the left hemisphere. Reduced gray matter (GM) volume was noted in the OSA group in multiple frontal regions of the left hemisphere (superior frontal, rostral medial frontal, and caudal medial frontal regions). Reduced white matter (WM) volume in both the left and right hemisphere was observed in regions of the frontal, parietal, and occipital lobes in children with OSA. This study noted differences in cortical thickness and GM and WM regional brain volumes in children with OSA. These findings are consistent with other pediatric studies, which also report differences between healthy children and those with OSA. We found that the severity of OSA does not correlate with the extent of MRI alterations.