Coagulation factor XII, XI, and VIII activity levels and secondary events after first ischemic stroke

• Published in: Journal of thrombosis and haemostasis 2020-12, Vol.18 (12), p.3316-3324
• Main Authors: Rohmann, Jessica L., Huo, Shufan, Sperber, Pia S., Piper, Sophie K., Rosendaal, Frits R., Heuschmann, Peter U., Endres, Matthias, Liman, Thomas G., Siegerink, Bob
• Format: Article
• Language: English
• Subjects: Adolescent; Brain Ischemia - diagnosis; Cardiovascular diseases; Cerebral infarction; coagulation; Coagulation factor XII; Coagulation factors; factor VIII; Factor XI; Factor XII; Humans; Ischemia; Ischemic Stroke; Myocardial infarction; Proportional Hazards Models; Prospective Studies; Risk Factors; Stroke; Stroke - diagnosis
• ISSN: 1538-7933; 1538-7836; 1538-7836
• DOI: 10.1111/jth.15092

Background Though risk for recurrent vascular events is high following ischemic stroke, little knowledge about risk factors for secondary events post‐stroke exists. Objectives Coagulation factors XII, XI, and VIII (FXII, FXI, and FVIII) have been implicated in first thrombotic events, and our aim was to estimate their effects on vascular outcomes within 3 years after first stroke. Patients/Methods In the Prospective Cohort with Incident Stroke Berlin (PROSCIS‐B) study, we followed participants aged 18 and older for 3 years after first mild to moderate ischemic stroke event or until occurrence of recurrent stroke, myocardial infarction, or all‐cause mortality. We compared high coagulation factor activity levels to normal and low levels and also analyzed activities as continuous variables. We used Cox proportional hazards models adjusted for age, sex, and cardiovascular risk factors to estimate hazard ratios (HRs) for the combined endpoint. Results In total, 94 events occurred in 576 included participants, resulting in an absolute rate of 6.6 events per 100 person‐years. After confounding adjustment, high FVIII activity showed the strongest relationship with the combined endpoint (HR = 2.05, 95% confidence interval [CI] 1.28–3.29). High FXI activity was also associated with a higher hazard (HR = 1.80, 95% CI 1.09–2.98), though high FXII activity was not (HR = 0.86, 95% CI 0.49–1.51). Continuous analyses yielded similar results. Conclusions In our study of mild to moderate ischemic stroke patients, high activity levels of FXI and FVIII but not FXII were associated with worse vascular outcomes in the 3‐year period after first ischemic stroke.