Cobalt-catalyzed ring-opening addition of azabenzonorbornadienes via C(sp 3 )–H bond activation of 8-methylquinoline

The first ring-opening addition of a benzylic C(sp 3 )–H bond to azabenzonorbornadienes is demonstrated. The reaction proceeded under the catalytic system of [Cp*CoI 2 (CO)], AgSbF 6 and Fe(OAc) 2 in PhOMe. The methodology showed a good substrate scope with up to 96% yield. The relative configuratio...

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Bibliographic Details
Published in:Chemical communications (Cambridge, England) England), 2020-10, Vol.56 (83), p.12570-12573
Main Authors: Tan, Heng, Khan, Ruhima, Xu, Dandan, Zhou, Yongyun, Zhang, Xuexin, Shi, Guangrui, Fan, Baomin
Format: Article
Language:English
Subjects:
Configurations
Crystallography
Hydrogen bonds
Ring opening
Substrates
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Summary:The first ring-opening addition of a benzylic C(sp 3 )–H bond to azabenzonorbornadienes is demonstrated. The reaction proceeded under the catalytic system of [Cp*CoI 2 (CO)], AgSbF 6 and Fe(OAc) 2 in PhOMe. The methodology showed a good substrate scope with up to 96% yield. The relative configuration of the product was determined as cis -configuration by X-ray crystallography.
ISSN:1359-7345
1364-548X
DOI:10.1039/d0cc05374k