Digging metagenomic data of pangolins revealed SARS‐CoV‐2 related viruses and other significant viruses

Pangolin metagenomic data obtained from public databases were used to assemble partial or complete viral genomes showing genetic relationship to severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2), Sendai virus, flavivirus, picornavirus, parvovirus, and genomovirus, respectively. Most of th...

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Bibliographic Details
Published in:Journal of Medical Virology 2021-03, Vol.93 (3), p.1786-1791
Main Authors: Yang, Shixing, Shan, Tongling, Xiao, Yuqing, Zhang, Heteng, Wang, Xiaochun, Shen, Quan, Wang, Yan, Yao, Yuxin, Liu, Qi, Wang, Hao, Zhang, Wen
Format: Article
Language:English
Subjects:
Animals
Coronaviridae
Coronaviruses
COVID-19 - virology
Genetic relationship
Genome, Viral - genetics
Genomes
Host Specificity - genetics
Metagenome - genetics
Metagenomics
Metagenomics - methods
pangolin
Pangolins - virology
Parvoviruses
Phylogeny
Recombination
Recombination, Genetic - genetics
SARS-CoV-2 - genetics
SARS‐CoV‐2‐related virus
Severe acute respiratory syndrome
Severe acute respiratory syndrome coronavirus 2
Viral diseases
Virology
Viruses
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Summary:Pangolin metagenomic data obtained from public databases were used to assemble partial or complete viral genomes showing genetic relationship to severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2), Sendai virus, flavivirus, picornavirus, parvovirus, and genomovirus, respectively. Most of these virus genomes showed genomic recombination signals. Phylogeny based on the SARS‐CoV‐2‐related virus sequences assembled in this study and those recently published indicated that pangolin SARS‐CoV‐2‐related viruses were clustered into two sub‐lineages according to geographic sampling sites. These findings suggest the need for further pangolin samples, from different countries, to be collected and analyzed for coronavirus to elucidate whether pangolins are intermittent hosts for SARS‐CoV‐2.
ISSN:0146-6615
1096-9071
DOI:10.1002/jmv.26524