The SSPN Score, a Novel Scoring System Incorporating PBRM1 Expression, Predicts Postoperative Recurrence for Patients with Non-metastatic Clear Cell Renal Cell Carcinoma

Background The loss of PBRM1 expression (as identified by immunohistochemistry) is associated with a high risk of postoperative recurrence for patients with clear cell renal cell carcinoma (ccRCC). The authors developed a scoring system to predict recurrence based on clinicopathologic factors incorp...

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Bibliographic Details
Published in:Annals of surgical oncology 2021-04, Vol.28 (4), p.2359-2366
Main Authors: Ohsugi, Haruyuki, Yoshida, Takashi, Ohe, Chisato, Ikeda, Junichi, Sugi, Motohiko, Kinoshita, Hidefumi, Tsuta, Koji, Matsuda, Tadashi
Format: Article
Language:English
Subjects:
Biomarkers, Tumor - genetics
Carcinoma, Renal Cell - surgery
Clear cell-type renal cell carcinoma
DNA-Binding Proteins
Humans
Immunohistochemistry
Kaplan-Meier Estimate
Kidney cancer
Kidney Neoplasms - surgery
Mathematical models
Medicine
Medicine & Public Health
Metastases
Metastasis
Necrosis
Neoplasm Recurrence, Local - surgery
Nephrectomy
Oncology
Postoperative period
Prediction models
Prognosis
Retrospective Studies
Risk groups
Statistical analysis
Surgery
Surgical Oncology
Transcription Factors
Urologic Oncology
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Summary:Background The loss of PBRM1 expression (as identified by immunohistochemistry) is associated with a high risk of postoperative recurrence for patients with clear cell renal cell carcinoma (ccRCC). The authors developed a scoring system to predict recurrence based on clinicopathologic factors incorporating PBRM1 expression. Methods This study retrospectively reviewed 479 ccRCC patients who underwent radical surgery between 2006 and 2017. The study extracted a subset of 389 non-metastatic ccRCC patients for whom relevant clinicopathologic factors were available. The primary end point was recurrence-free survival (RFS). The Kaplan–Meier method and the Cox proportional hazards model were used for statistical analysis. Leibovich score, SSIGN score, and University of California, Los Angeles (UCLA) Integrated Staging System were included as conventional prediction models. Results Of the 389 patients, 53 (13.6%) experienced recurrence during a median period of 61 months. Multivariable analyses showed that that the independent factors for RFS were ≥ pT3 (hazard ratio [HR] 3.64; P  
ISSN:1068-9265
1534-4681
DOI:10.1245/s10434-020-09075-4