Distribution and Progression of Inflammatory Chorioretinal Lesions Related to Multifocal Choroiditis and Their Correlations with Clinical Outcomes at 24 Months

To analyze distribution and progression of multifocal choroiditis (MFC) inflammatory lesions and their correlations with clinical outcomes at 24 months. Distribution and progression of inflammatory lesions were evaluated in eyes with MFC using a semi-automatic approach based on fundus autofluorescen...

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Bibliographic Details
Published in:Ocular immunology and inflammation 2022-02, Vol.30 (2), p.409-416
Main Authors: Erba, Stefano, Cozzi, Mariano, Xhepa, Alba, Cereda, Matteo, Staurenghi, Giovanni, Invernizzi, Alessandro
Format: Article
Language:English
Subjects:
Autofluorescence
Choroiditis - diagnosis
Choroiditis - pathology
Fluorescein Angiography - methods
Humans
inflammatory lesions
Multifocal Choroiditis
multimodal imaging
optical coherence tomography
punctate inner choroidopathy
Recurrence
Retrospective Studies
Tomography, Optical Coherence - methods
uveitis
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Summary:To analyze distribution and progression of multifocal choroiditis (MFC) inflammatory lesions and their correlations with clinical outcomes at 24 months. Distribution and progression of inflammatory lesions were evaluated in eyes with MFC using a semi-automatic approach based on fundus autofluorescence. Twenty-four-months clinical outcomes were correlated with baseline features. Twenty-five eyes from 20 patients were enrolled. Visual acuity (VA) significantly improved from baseline to 24 months. Chorioretinal lesions spared the fovea in most eyes. The area of inflammatory lesions at 24 months significantly increased. Final number and area of lesions were significantly influenced by baseline features. Inflammatory lesions enlarged over time regardless of MFC recurrences. New lesion and MFC relapses did not affect final outcomes. Final VA correlated with baseline VA. Scars resulting from MFC lesions enlarged overtime even when the disease was under control. New lesions and MFC relapses did not affect final outcomes.
ISSN:0927-3948
1744-5078
DOI:10.1080/09273948.2020.1800048