Design of Chitosan Nanocapsules with Compritol 888 ATO® for Imiquimod Transdermal Administration. Evaluation of Their Skin Absorption by Raman Microscopy

Purpose Design imiquimod-loaded chitosan nanocapsules for transdermal delivery and evaluate the depth of imiquimod transdermal absorption as well as the kinetics of this absorption using Raman Microscopy, an innovative strategy to evaluate transdermal absorption. This nanovehicle included Compritol...

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Bibliographic Details
Published in:Pharmaceutical research 2020-10, Vol.37 (10), p.195-195, Article 195
Main Authors: Alvarez-Figueroa, María Javiera, Narváez-Araya, Daniela, Armijo-Escalona, Nicolás, Carrasco-Flores, Eduardo A., González-Aramundiz, José Vicente
Format: Article
Language:English
Subjects:
Analysis
Animal experimentation
Biochemistry
Biomedical and Life Sciences
Biomedical Engineering and Bioengineering
Biomedicine
Imiquimod
Medical Law
Microscope and microscopy
Oxaprozin
Pharmacology/Toxicology
Pharmacy
Raman spectroscopy
Research Paper
Skin
Transdermal medication
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Summary:Purpose Design imiquimod-loaded chitosan nanocapsules for transdermal delivery and evaluate the depth of imiquimod transdermal absorption as well as the kinetics of this absorption using Raman Microscopy, an innovative strategy to evaluate transdermal absorption. This nanovehicle included Compritol 888ATO®, a novel excipient for formulating nanosystems whose administration through the skin has not been studied until now. Methods Nanocapsules were made by solvent displacement method and their physicochemical properties was measured by DLS and laser-Doppler. For transdermal experiments, newborn pig skin was used. The Raman spectra were obtained using a laser excitation source at 532 nm and a 20/50X oil immersion objective. Results The designed nanocapsules, presented nanometric size (180 nm), a polydispersity index
ISSN:0724-8741
1573-904X
DOI:10.1007/s11095-020-02925-6